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《Journal of Hubei University of Chinese Medicine》 2009-06
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Experimental Study on Anti-mutation Effect of Gynostemma pentaphyllum

NI Ya,XU Yun-dan,ZHAO Gang(Hubei University of Chinese Medicine,Wuhan 430061,Hubei)  
objective To accurately determine the anti-mutation of the aqueous extract of Gynostemma pentaphyllum.Methods They used world-wide adopted means [Ames test,Sister chromatid exchanges test in the lymphocytes of human blood,Micronucleus test in the lymphocytes of human blood,Chromosomal aberration test of CHO cells] to systematically study the anti-mutation of Gynostemma under different doses.Results: All three dose groups for Gynostemma pentaphyllum can restrain the increase of the back matagenesis of TA98 induced by 2,7-AF,high dose groups are especially effective(P0.01),a inhibition rate of 58.0% respectively.Median dose group can restrain the increase of the back matagenesis of TA100 induced by NaN3(P0.05),high dose group shows significant effect(P0.01,47.2% inhibition rate).High and Median dose group inhibits the increase of SCE] in the lymphocytes of human blood induced by MMC(P0.05).All three dose groups for Gynostemma pentaphyllum can restrain the increase of MN in the lymphocytes of human blood induced by MMC,high and median dose groups are especially effective(P0.01).High does group for Ginseng inhibits the Chromosomal aberration of CHO cells induced by MMC.While all three dose groups for Gynostemma pentaphyllum inhibit the Chromosomal aberration of CHO cells induced by MMC,and show clear dose-effect relationship(P0.05).The high dose groups is especially effective(P0.01),it show inhibition rate 49.15% respectively.Conclusions Gynostemma pentaphyllum show good anti-mutant activity in vitro genetic toxicology test systems.
【Fund】: 湖北省高等学校科学研究青年发展项目资助 [96C07]
【CateGory Index】: R285.5
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