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《Health Research》 2009-02
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Effect of ethy1 acetate extract from bergamot in asthmatic mouse model

YIN Hong-ping,XU Shun-mei(Department of Basic Medical Science,Hangzhou Normal School,Hangzhou,Zhejiang 310036,China)  
Objective To explore the effect of ethy1 acetate extract from bergamot(EAEB)on inflammation leukocytes in asthmatic mouse model. Methods The asthmatic mouse model was established by sensitization of intraperitoneal injection and atomized stimulation with ovalbumin(OVA).Some asthma model mice were intervened with EAEB(EAEB group) and others were positive control by receiving dexamethasone(DXM) treatment(DXM group).The number of leukocytes and eosinophils in peripheral blood was counted and pathological change of pulmonay tissue was examined. Results Compared with the asthmatic group,the number of leukocytes,eosinophils and lymphocytes in the peripheral blood of EAEB group and DXM group were significantly lower(P0.05 and P0.01,respectively),while no significant difference of these indices was found between the EAEB group and DXM group(P0.05).Pathological examination of lung tissue of asthmatic group showed that large amount of inflammation cells(eosinophils,plasmocytes and lymphocytes) were found surrounding the bronchius and vessels.Inflammation cell infiltration was also detected in pulmonary mesenchyme and alveolus and mucus secretion was found in airway epithelium.While compared with asthmatic group,the EAEB group and DXM group had less inflammation cells infiltration in lung tissue and no mucus secretion in airway epithelium. Conclusion EABA can suppress eosinophilic inflammation in asthmatic mice.
【Fund】: 杭州师范大学青年科研基金项目(2006xmq06)
【CateGory Index】: R285.5
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