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Research on Abnormal Methylation of DAPK1 Gene in Human Gastric Cancer

WANG Heling1 ZHANG Jian1 LI Yan2 1.Department of Gastroenterology,The First Hospital of Shenyang;2.Department of Gastroenterology,the Second Affiliated Hospital of China Medical University,Shenyang 110021,China  
Objective To study the situation of DAPK1 gene methylation and the expression of DAPK1 in human gatric cancer tissues.Methods The methylation of DAPK1 was detected by MSP,and the expression of DAPK1 was detected by RT-PCR.Results The low expression of DAPK1's mRNA is 16/35(P=0.465).The rate of DAPK1 gene methylation in human gastric cancer tissues and cancer-adjacent tissues is both 100%(P0.05).Conclusion The low expression of DAPK1 in gastric cancer tissues isn't related with the gene promoter's methylation.
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