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《Nervous Diseases and Mental Hygjene》 2005-01
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Prospective Study of Effects of Paroxetine with Mental Intervention on Depression and Anxiety after Stroke

He Yan, Wang Xin, Xiao Chunling, et al. (Department of Neurology, the Central Hospital of Railway Station, Ji’nan 250001, China)  
Objective To probe the influences of depression and anxiety on ability of daily life and neurologic functional rehabilitation, and the clinical curative effect of Paroxetine combined with psychotherapy. Methods 272 patients were assessed with SDS, SAS, the 81 patients with depression and anxiety were divided into 3 groups randomly, then treated with Paroxetine singly or Paroxetine combine with psychotherapy or not treated. SSS, BI, HAMD, HAMA were assessed to observe the curative effect before and after treatment. Results The attack rate of depression combined with anxiety in acute stroke was 29.78%, and the comorbidity was 65.85%. Depression and anxiety were related to the disease of frontal cortex, left brain and basal ganglia (frontal cortex P0.05, left brain P0.0001, basal ganglia P0.0001). The reducing of SSS, HAMD, HAMA grade and increasing of BI grade in treatment group I and group II were more obvious than that in control group (P0.01). The reducing of SSS, HAMD, HAMA grade and increasing of BI grade in treatment group II were more obvious than that in treatment group I (P all0.05). Conclusions Depress and anxiety were related to the position of stroke; It can obvious reduce the ability of daily life and neurologic functional rehabilitation; The Patients’ ability of daily life and the degree of neurologic functional rehabilitation all can be increased by applying either Paroxetine singly or Paroxetine combined with psychotherapy, but the curative effect of Paroxetine combined with psychotherapy was better.
【Key Words】: Stroke Depression Anxiety Comorbidity Prognosis Paroxetine Psychotherapy
【Fund】: 济南铁路局科研基金资助(02Y41-2)
【CateGory Index】: R749.1
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