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《Scientia Sinica(Chimica)》 2010-06
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Application and development of monolithic stationary phases for HPLC in pharmaceutical analysis and separation

YANG GengLiang & LIU HaiYan College of Pharmacy,Hebei University;Hebei Province Key Laboratory of Pharmaceutical Quality Control,Baoding 071002,China  
In recent years,monolithic supports as stationary phases in high-performance liquid chromatography(HPLC) have become a rapidly burgeoning field.This review summarizes the current achievements and their application in pharmaceutical analysis and separation.One kind is the silica monoliths prepared from tetraalkoxysilane by a sol-gel method with either micrometer-size through-pores or high specific surface areas and well suited for small molecules in HPLC modes.The other kind is the organic polymer-based monoliths including monolithic molecularly imprinted polymers in treatments of the samples before injected into the chromatograph in biological fluids.The analytical potential of these columns is demonstrated with separations involving various drugs in different chromatographic modes.
【Fund】: 国家自然科学基金项目(20375010&20675084);; 河北省科技攻关项目(06276479D&07276407D);; 河北省自然科学基金项目(B2007000146);; 河北省教育厅项目(2008416);; 河北大学自然科学基金项目(2009-165)资助
【CateGory Index】: R917
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