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《Journal of Integration Technology》 2017-06
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Review on Progress in Chemerin, an Adipokine, and Polycystic Ovarian Syndrome(PCOS)

SUN Lifeng;YANG Yali;HUANG Chen;XUE Li;ZHANG Jian;Research Laboratory for Reproductive Health, Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences;  
Polycystic ovarian syndrome is a disease with dysgenesis and metabolic disorders, which has the characteristics including the polycystic ovary and hyperandrogenism. In order to guide the diagnose the syndrome, three visions of diagnostic criteria were presented and implemented all over the world, the National Institutes of Health 1990 criteria, the Rotterdam 2003 criteria, and the Androgen Excess Society 2006 criteria. Many adipokines have effects on PCOS, which have the following biological fuctions, such as inflammatory response, immunoreaction, energy storage, and so on. Chemerin, a new adipokine, was found with higher concentration in PCOS patients, comparing the healthy, therole of which in the pathogenesis of PCOS was not clear. This review indicated the role of Chemerin in the pathological development which maintain the potential therapeutic target in PCOS.
【Fund】: 国家科技部973计划(2013CB945500);; 国家自然科学基金面上项目(31671562.00);; 深圳市基础研究学科布局(JCYJ20160331190714896)
【CateGory Index】: R711.75
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