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Study on Mechanism of Adenine-Induced Chronic Renal Failure in Rat

Zhou Xiaozhou ;Zhang Shengguang; Yang Xiao; Wei Yi (Hunan College of TCM, Changsha, China410007)  
The experiment was per formed in rats with feeding of adenine to produce metabloic abnormalities resembling chronic renal failure in humans. The results showed that creatinine, BUN, SP, UP, blood lipid, SOD and LPO increased significantly in rats with adenine for twenty-one days,and GSH-Px deereased significantly,Histofogical findings in the kidneys revealed uroliths,there was formation of foreign body granuloma,fibrosis in the interstitium, degeneration and necrosis of the tubular epithelia, and so on. These results suggested that the mechanism of adenine-induced chronic renal fai1ure in rats may be caused by 2, 8vDihydroxyadenine (DHOA)which is the metabolic production of adenine to stimulate,obstruct and injure proximal and distal tubular lumina and interstitium,and to lead to the degeneration of the functions. As well as,increasing of OFR and the content of lipid Peroxide in serum also plays a role in the mechanism.
【Fund】: 湖南省教委资助;;湖南省卫生厅资助
【CateGory Index】: R692.5
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