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《Basic Medical Sciences and Clinics》 1999-04
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Nitric Oxide Inhibits VCAM-1 Expression of Human Endothelial Cell Activated by IL-1

Huo Yuqing; Xu Chengbin;Wang Shenwu et al(Dept. of Cardiology, People's Hospital, Beijing Medical University, Beijing100044)  
FCAS, cell ELISA and Nortnern blot were applied to study the effects of nitroprosside, a donorof nitric oxide on the expression of protein and mRNA of VCAM-1. Results showed that nitroprussideinhibit6d Expression of VCAM-1 protein and mRNA in a dose-and time-dependent manner. It impliesthat, inhibitory effect of nitric oxide on VCAM-1 expression could be one of the mechanismsunderlying antiadhesion between monocyte and vascular endothelial cells, and antiatherosclerosis. Correspondence to professor Xu Chengbin
【Key Words】: Nitric oxide Vascular adhesion molecule Endothelial cell
【CateGory Index】: R363
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