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《Basic Medical Sciences and Clinics》 2001-04
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Progresses in the screening of new microbial drugs

SI Shu yi, HUANG Ming yu, ZHANG Yue qin  
Microbial drugs are antibiotics and other pharmacological substances from the secondary metabolites of microorganisms Screening process includes collection of soil and ocean samples, isolation of microorganisms, fermentation, strain screening, isolation of bioactive components and structure elucidation Producing microorganisms includes streptomyces, rare actinomycetes, bacteria, fungi, and ocean microorganisms New strategy for screening new microbial drugs is the screening of novel anti resistant bacterial agents, antifungal agents, antiviral agents, antitumor substances, immunomodulators and pharmacological active substances
【CateGory Index】: R965.1
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Chinese Journal Full-text Database 5 Hits
1 LIANG Jian-guang, XIONG Xiao-hui, XIONG Qiang (College of Pharmacy and Life Science, Nanjing University of Technology, Nanjing 210009, China);Application of Microbial Metabolites to Preparation of Plasmin Medicine[J];Amino Acids & Biotic Resources;2003-02
2 WANG Li-li~(1),CHEN Qi-yu~(2)(1.Department of Microbiology and Immunology,Jiangsu University,Zhenjiang 212001;2.Department of Microbiologyand Immunology,Wannan Medical College,Wuhu 241001,China);Antagonistic activity of the (H_2O_2)~+ lactobacilli against E.coli in vitro[J];Basic & Clinical Medicine;2006-01
3 WANG Wei-yun (College of Life Science, Anhui Agricultural University, Hefei 230036, Anhui, China);Studies on the Ion Implantation on Grifola frondosa[J];Acta Laser Biology Sinica;2005-03
4 Li Xiao-Yu, Zhu Shun-Ya, Wei Yun-Ling, Yang Pei-Ying, Zhu Qing-Yu, Qing E-De * (Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China);Establishment and application of screening model for antiviral drugs targeting SARSin vitro[J];Bulletin of The Academy of Military(Medical Sciences);2003-05
5 XIONG Qiang 1 LIANG Jian-Guang XIONG Xiao-Hui (N anjing University of Technology Nanjing 210009 );MICROORGANISM——THE ORIGINATION OF THE THROMBOLYTIC AGENTS[J];Microbiology;2003-05
Chinese Journal Full-text Database 3 Hits
1 Zhang Ke, Zhang Yue qin, Wei Yu zhen, Si Shu yi, Li Yi and Zhen Yong su (Institute of Medicinal Biotechnology, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100050);Study on the anti-microtubule activity of the fermentation product of a Penicillium strain[J];CHINESE JOURNAL OF ANTIBIOTICS;2000-04
2 Ding Jian (Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031);NEW RESEARCH APPROACHES IN ANTI TUMOR DRUG[J];CHINESE NEW DRUGS JOURNAL;2000-03
3 Li Yuan (Department of Bioengineering, Institute of Medicinal Biotechnology, CAMS and PUMC, Beijing 100050,China);Introduction of the High Throughput Screening System[J];Acta Academiae Medicinae Sinicae;2000-02
Chinese Journal Full-text Database 10 Hits
1 WANG Ying-jian(Liaoning Petrochemical College of Technology,Jinzhou,Liaoning 121001);Study on Isolation Purification and Identification of Phosphate-Solubilizing Bacteria and Its Biological Characteristics[J];Journal of Anhui Agricultural Sciences;2008-32
2 YAO Tuo,ZHANG De-gang,HU Zi-zhi (Pratacultural College,Gansu Agricultural University,Lanzhou 730070,China);Associative nitrogen-fixing bacteria in the rhizosphere of Avena sativa in an alpine region Ⅰ Isolation and identification[J];Acta Pratacultural Science;2004-02
3 YAO Tuo (Pratacultural College, Gansu Agricultural University, Lanzhou 730070, China);Associative nitrogen-fixing bacteria in the rhizosphere of Avena sativa in an alpine region Ⅱ Phosphate-solubilizing power and auxin production[J];Acta Pratacultural Science;2004-03
4 YIN Hong-xing1, ZHANG Shu-jia1,2, ZHENG Xue-fang2, YANG Lan-yi1(1. College of Environment and Chemical Engineering, Dalian University, Dalian 116622, China;2. Liaoning Key Laboratory of Bioorganic Chemistry, Dalian University, Dalian 116622, China);Review in the Antitumor Research of Selenium[J];Journal of Dalian University;2008-06
5 TUO Ya 1, SU Xiu Lan 1, LU Gui Rong 1, XIN Xue Dong 1, WANG Wen Li 1, KE Yang 1, BAO Wen Yu 2 (1. Laboratory of Cytogenetics, Beijing Institute for Cancer Research, Medical College, Beijing University, Beijing 100034, China; 2. Shanghai United;Analysis of gene expression patterns in antiangiogenesis Traditional Chinese Medicine by cDNA microarray[J];Academic Journal of Second Military Medical University;2002-03
6 Li Ming and others;Studies on the Phosphorization of JF88 Strain of Silicate Bacteria[J];JOURNAL OF DALI TEACHERS COLLEGE;2000-02
7 LI Yuqiang.The First People's Hospital of Pingdingshan,Pingdingshan 467000,Henan;Drug resistance of 480 strains of Pseudomonas aeruginosa[J];Clinical Medicine;2006-09
8 SUN Dan-feng,YANG Xiang-hua,PIAO Yu-hua(School of Environmental and Biology Engineering,Liaoning University of Petroleum & Chemical Technology,Fushun Liaoning 113001,P.R.China);Screening of Antagnologic Actinomyces Strain in Soil and the Initial Research of Strain YYHS-2[J];Journal of Liaoning University of Petroleum & Chemical Technology;2008-03
9 CHEN Yi-lin~1, ZHANG Cheng-lai~2(1.Hunan Linli Plantpreotection Station,Linli 415200, China; 2.Hunan research institute of chemical industy/Hunan Branch of the National Southern Pesticide Research and Development Center , Changsha 410007,China);Development of the microorganism source activity material and creating new chemical pesticide[J];Guangdong Agricultural Science;2005-03
10 YANG Chuanbiao XU KechengGuangzhou Fuda cancer hospital;Function of Anti-tumor of Chinese Medication[J];International Medicine & Health Guidance News;2004-18
China Proceedings of conference Full-text Database 1 Hits
1 Zheng Wei,Cheng Yuanrong Institute of Microbiology,State Pharmaceutical Administration of China and Fujian Province,Fuzhou,350007;The Importance of Searching New Strains for Screening New Microbial Products[A];[C];1999
Chinese Journal Full-text Database 10 Hits
1 Hong Shengming,Zhan Lifen,Zhang Yuzhi,et al. Dept. of Pathology,China Medical University,The Third Hospital,Shenyang 110021;AN EXPERIMENTAL STUDY ON THE CARCINOGENIC EFFECT OF BEAUVERIA BASSIANA IN MICE[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1997-02
2 WANG Tan~1 CHEN Da-zhou~2 TANG Hua~2 LI Lei~1(1.School of Science,Beijing University of Chemical Technology,Beijing 100029;2.National Research Center for Certified Reference Materials,Beijing 100013,China);Simultaneous determination by HPLC of four kinds of antibiotics in seafood[J];Journal of Beijing University of Chemical Technology(Natural Science Edition);2006-05
3 QI Bi shu 1, YANG Wen xiang 2,LIU Da qun 2 (1. Center of Biotechnology,Agricultural University of Hebei,Baoding 071001 China; 2. Department of Plant Pathology, Agricultural University of Hebei, Baoding 071001, China);A preliminary study on antagonism of Streptomyces spp. against Curvularia leaf spot of maize[J];JOURNAL OF AGRICULTURAL UNIVERSITY OF HEBEI;2000-03
4 WEI Dong-sheng,CHEN Yun-fang,LIU Da-qun (College of Plant Protection,Agricultural University of Hebei,Baoding 071001,China);Effects of Bacillus strain B21 and its fermented liquor on Botrytis cinerea C31 on Tomato[J];Journal of Agricultural University of Hebei;2002-04
5 DUAN Qi-mei~1,MU Xiao-qian~1,AN De-rong~2,LIU Cui-juan~2 (1 College of Life Science,Northwest Sci-Tech Agriculture and Forestry University, Yangling,Shaanxi 712100,China;2 College of Plant Protection, Northwest Sci-Tech Agriculture and Forestry Unive of Education of The People's Republic of China, Yangling,Shaanxi 712100,China);Study on inhibiting range and mechanism of S-159-06 active product[J];Acta Botanica Boreali-occidentalia Sinica;2004-06
6 SHU Xiu-lin,AN De-rong est Management Ministry of Education,The People's Republic of China,Northwest Sci-Tech University of Agriculture and Forestry,Yangling,Shaanxi 712100,China);Studies on the effect of zuelaemycin producing actinomycetes strain S-5120 on downy mildew of cucumber[J];Acta Botanica Boreali-occidentalia Sinica;2004-11
7 WU Xiao-lin~1, HOU Zhao-wei~2, CHEN Jian~1, LUN Shi-yi~1( 1. School of biotechnology, Southern Yangzte University, Wuxi, Jiangsu 214036, China; 2. Institute of Petroleum E & D, Daqing Oil Field Corp. Ltd. Daqing, Heilongjiang 163712, China );The microbial degradation of Daqing crude oil by selected bacteria[J];Journal of Daqing Petroleum Institute;2004-06
8 Wang Guiying Hu Jieyu Yan Yujuan (Department of Virology, Wuhan University);ACTION OF CYTOCHALASIN D ON CELLS OF MOUSE MAMMARY ADENOCARClNOMA CELL LINE (MA782/5S-8102)[J];Zoological Research;1986-01
9 XIAO Tian (Institute of Oceanology, CAS, Qingdao 266071,China);THE STUDY ON MARINE BACTERIOPLNAKTON ECOLOGY[J];Advance In Earth Sciences;2001-01
10 GONG Liang-yu~1, WANG Xiu-lin~1, LI Yan-bin~2, ZHANG Chuan-song~1, LI ANG Sheng-kang~1, Zhu Chen-jian~1 (1.Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266003,China;2.College of Marine Life Science, Ocean University of China , Qingdao 266003,China);Isolation and Purification of Phenazine Pigments Produced by Pseudomonas aeruginosa and its Effects on the Growth of Red Tide Organisms[J];Journal of Fudan University;2004-04
China Proceedings of conference Full-text Database 1 Hits
1 Guo Gang, Hong Kui, Hu Shencai, Xiao Chun , Yan Liping , Zheng Fucong, (State Key Laboratory of Tropical Crop Biotechnology, Haikou, 571101) ( Environment and Plant Protection Institute of Chinese Academy of Tropical Agricultural Science, Danzhou, Hainan, 571737) ( Key Lab of Agricultural Microbiology, Department of Agriculture&Education, Huazhong Agricultural University, Wuhan, 430070) ( Engineering School of South China University of Tropical Agriculture, Danzhou, 571737);SCREENING OF MARINE MICROORGANISMS AGAINST RICE BLAST PATHOGEN[A];[C];2003
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 YANG Jie-jing, QIAN Xiu-ping, ZHAO Feng-sheng(School of Pharmacy, Shanghai Jiao Tong University,Shanghai 200240);Mutation breeding of Termitomyces albuminosus producing anti-coagulation protein TA-P[J];Industrial Microbiology;2007-03
2 WANG Shu-jing(School of Pharmaceutical Sciences,Shandong University of Traditional Chinese Medicine,Jinan 250355);New Biological Technology Application in Natural Medical Research[J];Journal of Beijing Union University(Natural Sciences);2010-03
3 YAN Shuang1,WU Hong-sheng1,ZHOU Xiao-dong1,ZHANG Fu-cun1,LIU Xiao-xue1,WANG Zeng-hui1,KONG Xiang-yun1,LIU Zheng-zhu2(1.Department of Agricultural Resources and Enviroment,Nanjing University of Information Science and Technology,Nanjing 210044,China;2.Agricultural Bureau of Huai'an City,Huai'an 223001,China);Progress of Biological Control for Cucumber Fusarium Wilt[J];Shandong Agricultural Sciences;2011-01
4 FEI Shang-fen,ZHANG Ping-ping,LI Bao-ku,ZHANG Xiao-yan(College of Life Sciences,Hebei University,Baoding 071002,China);Studies on the Fermentation Conditions of a Fibrinolytic Enzyme High-producing Strain[J];Journal of Hebei University(Natural Science Edition);2006-03
5 NIE Ya-feng1,LIU Yong-feng2,LI De-quan1,LIU You-zhou2,LUO Chu-ping2,CHEN Zhi-yi2 (1.College of Plant Protection,Nanjing Agricultural University,Nanjing 210095,China;2.Institute of Plant Protection,Jiangsu Academy of Agricultural Sciences,Nanjing 210014,China);Marine Bacteria with Antimicrobial Activity against Rice Sheath Blight[J];Jiangsu Journal of Agricultural Sciences;2007-05
6 JI Xiao-guang,ZHAO Guang-yu,SHI Xin-fu,ZHANG Liang-yan,ZHANG Song-le,ZHAO Yan-hong,Wang Jing-yan,Wang Xi-liang (State Key Laboratory of Pathogen and Biosecurity,Institute of Microbiology and Epidemiology,Academy of Military Medical Sciences,Beijing 100071,China);Anti-SARS-CoV capability of remedial horse anti-SARS-CoV immunoglobulins[J];Immunological Journal;2006-05
7 NIU Shu-min1,YUAN Hong-shui2,LI Shu-na2,WANG Shi-ying2,ZHANG Ai-lian1,ZHU Bao-cheng1,2(1.School of Life Science,Hebei University,Baoding 071002,China;2. School of Life Science,Agriculture University of Hebei,Baoding 071001,China);Optimization of fermentation process on the fibrinolytic enzyme producing strain BS-26[J];Chinese Journal of Biochemical Pharmaceutics;2008-01
8 NIU Shu-min1,2,LI Shu-na1,GUO Xiao-jun1,YUAN Hong-shui1,WANG Shi-ying1,ZHU Bao-cheng1 (1.School of Life Science,Agriculture University of Hebei,Baoding 071001,China;2.No.1 Middle School of Baoding Heibei Province,Baoding 071000,China);Isolation and identification of the fibrinolytic enzyme producing strain BS-26[J];Chinese Journal of Biochemical Pharmaceutics;2008-03
9 CAO Jing1,2 ZHANG Ye3 PENG Zhi-gang1,2 LI Ji-xian1,2 WANG Shao-peng1,2 (1 Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China)(2 Graduate School of the Chinese Academy of Sciences, Beijing 100039, China)(3 HD Biosciences Co Ltd, Shanghai 201203, China);Establishment of a Cell Based High Throughput Screening Model for Discovering New Agonists of Histamine H3 Receptor[J];China Biotechnology;2008-09
10 ZHAO Wei1,FANG Dan-yun2,ZHOU Jing-jiao2,ZHANG Wen-bing1,YAN Hui-jun2,HU Zu-qiong1,LONG Bei-guo(1),JIANG Li-fang(2)(1.Department of Microbiology,Southern Medical University,Guangzhou 510515;2.Zhongshan Medical College Sun Yat-sen University,Guangzhou 510080,P.R.China);Establishment and Application of Cell Model Infected by SARS Coronavirus in Guangdong[J];Biotechnology;2005-01
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 Armand J P 1 , SUN Yan 2,GUAN Zhong zhen 3, LiyaJu 4? ? WTBX 1 Institute Gustave Roussy, 94800, Villejuif ,France 2 Chinese Academy of Medical Science Cancer Hospital, Beijing 100021,P R China 3 Cancer Center, Sun Yet sen Univer;Oxaliplatin in the treatment of advanced colorectal cancer——a review of clinical studies[J];CHINESE JOURNAL OF CANCER;1999-06
2 Wu Qian, Wu Jianbo and Li Yuan (Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050);Screening, purification and pharmacological study on a IL-1R antagonist Streptomyces 139[J];CHINESE JOURNAL OF ANTIBIOTICS;1999-06
3 Li Quan- wen, Bian Xin, Zhang Yang and Li Yuan (Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing10 0 0 5 0 );Study of the screening model for IL-1 receptor antagonists[J];CHINESE JOURNAL OF ANTIBIOTICS;2000-05
4 $$$$Cheng Yuanrong(Fujian Institute of Microbiology,SPAC,Fuzhou 350007);Immunosuppresents from microorganism origin[J];CHINESE JOURNAL OF NATIBIOTICS;1996-S1
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