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《Basic Medical Sciences and Clinics》 2001-06
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Changes of lung tissue matrix metallo proteinase and its tissue inhibitor in pulmonary fibrosis rats

HUANG Ri hong, WU Tai hua, ZHANG Zhong he (Pulmonary Department of the First affiliated hospital of Dalian Medical University, Dalian 116011)  
To explore the role of matrix metallo proteinase (MMPs) and their tissue inhibitor(TIMPs) in pathogenesis of pulmonary fibrosis. The animal model of pulmonary fibrosis was established by injecting bleomycin A5 into rat trachea(5mg/kg), furthermore, pulmonary pathologic changes and MMP 2?MMP 9 ?TIMP 1 were assessed for various time 1?3?7?14 and 28 days. MMPs and TIMPs were assessed by zymogram and Western Blot analysis. The Results showed that protein expression of ProMMP 2?MMP 2 and TIMP 1 were significantly increased in pulmonary fibrosis groups compared that in normal groups, especially level of MMP 2 ,which was augmented at 7?14 and 28 days. Nevertheless, the difference of MMP 9 between two groups had not been observed. We concluded that the markedly higher level of MMP 2 and TIMP 1 might be involved in the pathogenesis of disease. Moreover, it was suggested that the unbalance between MMP/TIMP seemste be the most important factor resulting in pulmonary fibrosis.
【CateGory Index】: R363
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