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《Basic Medical Sciences and Clinics》 2002-02
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The differential expression of NDR2 mRNA in tumors

LI Jian, YAO Li-Bo, LIN Shu-Xin, et al (Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an 710032,China)  
In order to explore the function of NDR2 gene, the expression of NDR2 mRNA in different human tissues and their relevant tumors was examined. Total RNA were extracted from human brain, glioma, lung and lung cancer, colon and carcinoma of colon, stomach and carcinoma of stomach. Reverse-transcription PCR (RT-PCR) was used to quantitate the relative abundance of NDR2 mRNA. NDR2 mRNA was found to be extensively expressed in the tissues. There were a higher expression level in normal brain and lung tissue than glioma and lung cancer respectively, while no difference was observed between colon and carcinoma of colon, stomach and carcinoma of stomach. These results suggest a possible involvement of NDR2 in the generation and progression of glioma and lung cancer.
【Fund】: 国家自然科学基金(39870 718) ;; 国家杰出青年科学基金 (3982 5 113)
【CateGory Index】: R73-34
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