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《Basic Medical Sciences and Clinics》 2003-01
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Effect of cholecystokinin octapeptide on IL-6 secretion by rat synovial cell line

ZHAO Zhan sheng, JIN Yu huai, XU Jin rong, et al . (Department of Pathophysiology,Hebei Medical University,Shijiazhuang 050017, China)  
To investigate the effect of cholecystokinin octapeptide(CCK 8) on the secretion of IL 6. The rat fibroblast like synovial cell line RSC 364 was stimulated with TNF. IL 1 and IL 6 concentration was measured by ELISA. The results showed that: CCK 8, at concentrations of 10 -6 mol/L and 10 -8 mol/L, significantly enhanced the production of IL 6 by this cell line after 24 hours of induction. The stimulating effect was inhibited by CCK 8 antagonist proglumide. These results suggested that:CCK 8 could regulate the IL 6 secretion by synoviocytes and may play a role in the pathogenesis of rheumatoid arthritis.
【CateGory Index】: R593.22
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