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《Basic Medical Sciences and Clinics》 2005-07
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Effect of cholecystokinin octapeptide on diabetic cataract of rats

HAO Li-na ~(1),WANG Qiu-hong ~(1),LING Yi-ling ~(1),MENG Xiang-yan ~(1),ZHANG Xiao-jing ~(1),LIANG Jun-qing ~(1),XIAN Xiao-hui ~(1),HE Shou-zhi ~(2)(1.Department of Pathophysiology of Hebei Medical University,Shijiazhuang,050051;2.Department of Ophthalmology of P.L.A.General Hospital,Beijing,100866)  
Objective To observe the effect of cholecystokinin octapeptide(CCK-8) on diabetic cataract in rats.Methods Diabetic cataract animal model was established by streptozotocine(STZ).Thirty-six rats were taken as Control group,seventy two rats were given peritoneal injection STZ((45 mg/kg)) and then divided into STZ group and treatment(peritoneal injection CCK-8,(100 μg/Kg)) group.The changes of induced nitric oxide(iNOS) mRNA,iNOS protein,production of nitric oxide(NO),the activity of nitric oxide synthase(NOS) and pathological changes of lens epithelium cell(LEC) were observered at 20~(th),40~(th),60~(th)day respectively.Results There was no distinct expressions of iNOS mRNA and iNOS protein in control group,along with lower content of NO and of NOS as well as normal LEC.But in STZ group,there were distinct up-regulation of iNOS mRNA and iNOS protein,along with higher content of NO and activity of NOS as well as abnormal LEC with time lengthening.Whereas to those with CCK-8 showed down-regulation of iNOS mRNA and iNOS protein,along with lower content of NO and activity of NOS as well as relative normal LEC. CCK-8 could reverse the damage of lens and the mechanism may be related to the inhibition the expression of iNOS and decreasing the formation of NO.
【CateGory Index】: R587.2
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