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《Basic Medical Sciences and Clinics》 2005-07
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Effect of cholecystokinin octapeptide on diabetic cataract of rats

HAO Li-na ~(1),WANG Qiu-hong ~(1),LING Yi-ling ~(1),MENG Xiang-yan ~(1),ZHANG Xiao-jing ~(1),LIANG Jun-qing ~(1),XIAN Xiao-hui ~(1),HE Shou-zhi ~(2)(1.Department of Pathophysiology of Hebei Medical University,Shijiazhuang,050051;2.Department of Ophthalmology of P.L.A.General Hospital,Beijing,100866)  
Objective To observe the effect of cholecystokinin octapeptide(CCK-8) on diabetic cataract in rats.Methods Diabetic cataract animal model was established by streptozotocine(STZ).Thirty-six rats were taken as Control group,seventy two rats were given peritoneal injection STZ((45 mg/kg)) and then divided into STZ group and treatment(peritoneal injection CCK-8,(100 μg/Kg)) group.The changes of induced nitric oxide(iNOS) mRNA,iNOS protein,production of nitric oxide(NO),the activity of nitric oxide synthase(NOS) and pathological changes of lens epithelium cell(LEC) were observered at 20~(th),40~(th),60~(th)day respectively.Results There was no distinct expressions of iNOS mRNA and iNOS protein in control group,along with lower content of NO and of NOS as well as normal LEC.But in STZ group,there were distinct up-regulation of iNOS mRNA and iNOS protein,along with higher content of NO and activity of NOS as well as abnormal LEC with time lengthening.Whereas to those with CCK-8 showed down-regulation of iNOS mRNA and iNOS protein,along with lower content of NO and activity of NOS as well as relative normal LEC. CCK-8 could reverse the damage of lens and the mechanism may be related to the inhibition the expression of iNOS and decreasing the formation of NO.
【CateGory Index】: R587.2
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 ZHU WEN-YU;JIN YU-SUN(Research Laboratory in Physiology of Digestion and Reproduction,Institute of Basic Medical Science,Beijing Medical University);PROTECTION AGAINST STREPTOZOTOCIN-INDUCED DIABETES BY CHOLECYSTOKININ-OCTAPEPTIDE IN MICE[J];Acta Physiological Sinica;1985-06
2 LING YI-LING AND SHAN-SHENG(Institute of Basic Medicine,Hebei Medical University,Shijiazhuang 050017)WANG LE-FENG,ZHANG JUN-LAN WAN MEI AND HAO RONG-LI;CHOLECYSTOKININ-OCTAPEPTIDE (CCK-8)REVERSES EXPERIMENTAL ENDOTOXIN SHOCK[J];ACTA PHYSIOLOGICA SINICA;1996-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LING Yi-ling,HUANG Xin-li(Department of Pathophysiology,Hebei Medical University,Shijiazhuang 050017,China);Importance of the role of endogenous anti-shock material in shock[J];Journal of Traumatic Surgery;2008-03
2 XU Shun-Jiang,GAO Wei-Juan ,YAO Yu-Xia,GU Zhen-Yong ,CONG Bin (. Department of Pathophysiology,Hebei Medical University,Shijiazhuang 05007,China; 2. Hebei Center of Disease Control);Effect of lipopolysaccharides on expression of cholecystokinin receptor mRNA in rat pulmonary interstitial macrophages[J];Academic Journal of Second Military Medical University;2003-11
3 GAO Feng,GU Zhen-yong,PING Jing,LIU Xia,ZHAO Li,XU Jin-rong,NI Zhi-yu,CONG Bin,LING Yi-ling((Department) of Forensic Medicine, Heibei Medical University,Shijiazhuang 050017,China);Inhibitive effect of cholecystokinin octapeptide on iNOS expression induced by lipopolysaccharide in ECV-304[J];Acta Academiae Medicinae Militaris Tertiae;2006-19
4 MA Li-Qin, GU Zhen-Yong, DONG Guo-Kai, LI Na, GAO Feng, LIU Xia, MA Chun-Ling, CONG Bin, LING Yi-Ling Department of Forensic Medicine and Pathophysiology, Hebei Medical University, Shijiazhuang 050017, China;Effect of cholecystokinin octapeptide on LPS-induced SOD mRNA expression and increase of NF-κB activity in rat vascular smooth muscle cells induced by LPS[J];Journal of the Fourth Military Medical University;2006-20
5 JIN Yu huai ,ZHAO Zhan sheng,XU Jin rong,LIU Pin li,LI Shu jin,LING Yi ling,CONG bin. Department of Pathophysiology,Hebei Medical University,Shijiazhuang 050017,China Corresponding author:CONG bin,050017,Department of Pathophysiology,Hebei Medical University,Shijiazhuang,China;Effects of cholecystokinin octapeptide-8 on the proliferation of rat fibroblast-like synovial cells and its possible molecular mechanism[J];Chinese Journal of Rheumatology;2003-03
6 Tan Jianyun Department of Pathophysiology Guangdong Medical and Pharmaceutical College;EXPERIMANTAL STUDY ON THE ACTION OF GLUTINOUS REHMANNIA MIXTURE IN REDUCING BLOOD SUGAR[J];;1989-02
7 Hu Lijuan 1,Wang Zhijie 1, Zhu Shengwei 2,Yao Changyou 2, Zheng Xiang 1, Ding Peng 3 (1.School of Life Science, Hubei University, Wuhan 430062,China; 2.Hospital of Hubei University, Wuhan 430062, China; 3.Department of Traditional Chinese Medicin;Influence of Yitangfang, a traditional Chinese medicine, upon the high blood sugar of the experimental mice contracting streptozotocin diabetes[J];Journal of Hubei University(Natural Science Edition);2001-01
8 ZHAO Zhan sheng, JIN Yu huai, XU Jin rong, et al . (Department of Pathophysiology,Hebei Medical University,Shijiazhuang 050017, China);Effect of cholecystokinin octapeptide on IL-6 secretion by rat synovial cell line[J];Basic Medical Sciences and Clinics;2003-01
9 NI Zhi-yu, LI Shu-jin, CONG Bin, YAO Yu-xia, WANG Chun-yan(The School of Basic Medical Sciences,Hebei Medical University,Shijiazhuang 050017,China);Inhibitory effect of CCK-8 on the expressions of TLR4 and IL-1β in LPS-induced pulmonary interstitial macrophages of rats[J];Basic Medical Sciences and Clinics;2005-02
10 GU Zhen Yong (Department of Pathophysiology, Hebei Medical University, [WT5”BZ]Shijiazhuang 050017) [WT5HZ];Peroxynitrite-Mediated Pulmonary Vascular Injury Induced by Endotoxin and the Protective Role of Cholecystokinin[J];Progress In Physiological Sciences;2001-02
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 GU ZENG-FA AND WANG CHIH-CHUN(Research Laboratory on the Physiology of Digeslion and Reproduction,Institute of Basic Medical Sciences,Beijing Medical College);PROTECTIVE EFFECT OF BOVINE PANCREATIC POLY-PEPTIDE ON ACUTE PANCREATITIS IN THE RAT[J];Acta Physiological Sinica;1983-02
2 WANG JIN-LIN;ZHU WEN-YU(Research Laboratory in Physiology of Digestion and Reproduction,Institute of Basic Medical Science,Beijing Medical College);THE ROLE OF VAGO-INSULN SYSTEM IN DECREASING PLASMA FREE FATTY ACID OF NEURAL CHOLECYSTO KININ OCTAPEPTIDE[J];Acta Physiological Sinica;1984-03
3 MEI LIN;HAN JI-SHENG(Department of Physiology,Beijing Medical University,Beijing100083);CHOLECYSTOKININ-OCTAPEPTIDE ANTAGONIZES THE CENTRAL DEPRESSIVE EFFECT OF OPIOID PEPTIDES IN RATS[J];Acta Physiological Sinica;1991-02
4 Ling Yi-Ling, et al Department of Pathophysiology, Hebei Medical College, Shijiazhuang;The effect of naloxone on the electric activity of sympathetic nerve in rabbit SMAO shock[J];Chinese Journal of Pathophysiology;1986-02
5 Wang Le-Feng, Huang Shan-Sheng, et al Department of Pathophysiology, Medical College of Hebei, Shi jiazhuang;Clearance and detoxification of endotoxin by lung[J];Chinese Journal of Pathophysiology;1992-02
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