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《BASIC MEDICAL SCIENCES AND CLINICS》 1995-03
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NG-Nitro-L-Arginine Induces Sustained Hypertension in Rats

Gao Lianru Zhao Yuntao Shi Xiangyun Xiong Jianran Yang Ye Liu Guozhang zhang Jifeng Tian Qing Tang Chaoshu Tang Jian(Navy General Hospital)  
o explore whether prolonge administration of N ̄ g-Nitro-L-Arginine(L-NNA ) can inducesustained hypertension in rats. We divied thirty female Wistar rats into five groups according tothe duration of L-NNA treatment.L-NNA may induced significant hypertension in all rats. Bloodpressure was much higher in all treated groups than that in control group(P0.01).Heart ratesreduced at 1d and reduced significantly at 28d. Increase in heart weight was found in 28d group.Maximal constricting responses of aortic rings to ET and NE were significantly augmented anddose-dependent relaxation by Ach decreased markedly. The ET levels of plasma and tissue fromaoriic strip werc heigher and cGMP levels of aortic tissue were lower.Plasma AGT Ⅱand PRAwere reduced. Plasma MDA was increased.
【CateGory Index】: R544.102
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