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A Mouse Model of Learning and Memory Deficit Induced by Cerebral Ischemia

Li Wei Zhang Shiyi Zhao Huimin Yan Huijin(Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences)  
igation of bilateral carotid arteries in different duration with or without systemic hypoten-tion was carried on in mice.Then,by using neurological sign examination,locomotor activity andactive avoidance tests,a new mouse model similar to human cerebral ischemic dementia was estab-lished,in which general behavior and motor activity kept normal but learning and memory wasimpaired.Neuropathology showed that these mice had concrete damage of neurons in frontal cor-tex and hippocampus.
【Fund】: 国家自然科学基金
【CateGory Index】: R-332
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