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Study on Effect of Gisenosides on Hippocampal Synapse in Rat by Means of Morphometry

Wang Jian Lou Ailin (Dept.Physiology,the Institute of Clinical Medical Sciences,China Janan Friendship Hospital,Beijing100029)  
Using microscopy and morphometry,the changes of the surface density (Sv) and the numerical density (Nv) of the synapse and the mean area of the single synapse (S) in the above layer of the pyramidal cell of hippocampal CA 1,CA 3 and the molecular layer of hippocampal dentate gyrus (DG) induced by gisenosides (GSS) were studied.The results showed that Sv and Nv of the synapse in GSS group are more 47 68±6 63% and 42 57±16 22% than those in saline group respectively (P0 001).In CA 1,the increase of S in GSS group could be observed (P0 05).It means that GSS could mainly elevate the number of hippocampal synapse,but GSS could also increase the mean area of the single synapse in CA 1.The changes mentioned above may be one of the morphological fundament for evoking hippocampal LTP and promoting learning and memory behavior in rat induced by GSS.
【Fund】: 国家自然科学基金
【CateGory Index】: R338.13,R965
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