Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
Add to Favorite Get Latest Update

Influence of Permanent Occlusion of Bilateral Common Carotid Arteries onLearning and Memory Ability and Hippocampal Histomorphology in Rats

Liu Huibo Ye Cuifei Li Bin An Wenlin Li Lin(Department of Pharmacology,Capital Uinversity of Medica1 Sciences Xuan-Wu Hospita1,Beijing Key Laboratory of Brain Aging,Beijing 100053)  
Objective To investigate the cogenitive impairment and neuropathological damage in hippocam pus of rats following permanent occlusion of bilateral common carotid arteries(2OV).Methods The hippocampal histomorphology was observed and analyzed by an image processor,and learning and memory ability was tested using water maze.Results The time through all pathways in the water maze was prolonged and errors in passing the blind alleys obviously increased 30days after 2VO operation on rats.The learning and memory ability of the 2OV rats was still severely impaired and significant loss of the cells was observed in the CA1 subfield of hippocampus 60 days after the operation.Conclusions the progressive neuronal degeneration following the permanent 2OV is in part involved in chronic cerebral hypoperfusion induced long lasting deficits of learning and memory in rats.This animal models may be advantageous to the evaluation of drugs that prevent and treat vascular dementia.
【Fund】: 北京市科委资助
【CateGory Index】: R-332,R338.64
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 10 Hits
1 ;The research progress of cerebral anoxia and ischemiaanimal models[J];吉林医药学院学报;2015-04
2 ZHU Pinghui;Department of Pharmacy,Zhoushan Putuo People's Hospital;;Influence of Polyphenol Extract from Zanthoxylum Bungeanum Maxim.on Norepinephrine,5-hydroxytryptamine and Monoamine Oxidase in Brain Tissue of Rats With Post-Stroke Depression[J];浙江中西医结合杂志;2014-05
3 ZHANG Weijun;CHEN Mei;The First Clinical Medical College of Zhejiang Chinese Medical University,Zhejiang Provincial Hospital of Traditional Chinese Medicine;;Influence of Ditan Kaiqiao Formula on BDNF Protein in Hippocampus of Post-Stroke Depression Rat[J];中华中医药学刊;2014-05
4 ZHANG Weijun,QIU Tao(Department of Neurology,The First Clinical Medical College of Zhejiang Chinese Medical University, Zhejiang Provincial Hospital of Traditional Chinese Medicine,Hangzhou 310053,Zhejiang,China);Study on Neurons Protection o Different Treatments for Experimental Rat Hippocampal CA3 Area of Post-Stroke Depression(PSD)[J];中华中医药学刊;2013-06
5 LI Lin**,ZHANG Lan(Department of Pharmacology,Xuanwu Hospital of Capital Medical University,Key Laboratory for Neurodegenerative Diseases of Ministry of Education,Beijing 100053,China);Action Characteristics of Traditional Chinese Medicine in Treatment of Alzheimer′s Disease[J];生物化学与生物物理进展;2012-08
6 HONG Jie-fei,LI Jun-liang,ZHANG Zhao-qiang,JIE Xin-ming,ZHONG Zhi-guo,LUO Lei-ling(Guangdong Medical College,Zhanjiang 524001,Guangdong,China);Influence of Yuxing Changzhi Decoction on Levels of NE and 5-HT in Brain Tissue of Rats With Post-Stroke Depression[J];辽宁中医药大学学报;2012-02
7 WU Shu-zhi,YE Hua,ZHENG Xiang.The Third Clinical Medical Institute of Wenzhou Medical College,Wenzhou 325000,China;The experimental study on Donepezil used in the treatment of vasculsr dementia of rats[J];中外医学研究;2012-03
8 LI Ruijie*,BAI Liming,ZHANG Xiaoshuang.*Department of Stroke,Xinle City Hospital of Hebei Province,Hebei Province,Xinle 050700;Effect of Dihuangyinzi on learning and memory and MMP-2,MMP-9 of hippocampal matrix in rats with chronic cerebral hypoperfusion[J];河北中医;2011-10
9 ZHANG Gang1,WANG Fawei1,GENG Miao2,CHEN Liping1(1.Department of Traditional Chinese Medicine;2.Institute of Geratology, Chinese PLA General Hospital,Beijing 100853,China);Comparative proteomic analysis of hippocampus between chronic cerebral ischemia rats and normal controls[J];中南大学学报(医学版);2011-10
10 WANG Wei-bin1,Xu Cun-li1,Lu Pei-yuan2(1.Department of Neurology,Jining No.1 Hospital,Jining,272111 ;2.Hebei Province People Hospital,Shijiazhuang,050051);The morphology of neurons in vascular dementia mouse hippocampus CA1 area and the effect of huperzine[J];上海医药;2011-09
Chinese Journal Full-text Database 10 Hits
1 Sun Nian-xia;Gao Wei-juan;Yi Zhong-liang;Department of Pathophysiology,Chengde Medical University;Hebei Chemical and Pharmaceutical College;;Improved suture occlusion method to prepare focal cerebral ischemia reperfusion models in Sprague-Dawley rats[J];中国组织工程研究;2014-02
2 WANG Kai1,ZHANG Feng-yu1,WEI Xiu-e2,RONG Liang-qun2(1.School Graduate of Xuzhou Medical College,Xuzhou 221002,China; 2.No.2 Affiliated Hospital of Xuzhou Medical College,Xuzhou 221002,China);Effects of FKBP51 on Global Cerebral Ischemia/Reperfusion Injury[J];北华大学学报(自然科学版);2013-02
3 LIU Ying1,2,LI Lin1,ZHANG Lan1(1.Department of Pharmacology,Xuanwu Hospital of Capital Medical University,Key Laboratory for Neurodegenerative Diseases of Ministry of Education,Beijing 100053,China;2.Department of Pharmacy,Beijing Children′s Hospital,Beijing 100045,China);Effects of Tetrahydroxy-stilbene Glycoside on α-Synuclein Over-expression and Ubiquitin-Proteasome System in Gene-transfected PC12 Cells[J];中国药学杂志;2012-01
4 YIN Lin-lin,LIN Li-li,LI Lin(Xuan-wu Hospital of Capital Medical University,Education Ministry Key Laboratory for Neurodegenerative Disease,Beijing 100053,China);Effects of Epimedium Flavone on Pathological Characteristics of Experimental Autoimmune Encephalomyelitis Rats[J];中国药学杂志;2011-18
5 TONG Zhi-Qian,HAN Chan-Shuai,MIAO Jun-Ye,LU Jing,HE Rong-Qiao(State Key Laboratory of Brain and Cognitive Sciences,Institute of Biophysics,The Chinese Academy of Sciences,Beijing 100101,China);Excess Endogenous Formaldehyde Induces Memory Decline[J];生物化学与生物物理进展;2011-06
6 LUO YunFeng1,2,ZHANG Jie3,LIU NianQing4,LUO Yuan5 & ZHAO BaoLu1 1State Key Laboratory of Brain & Cognitive Science,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China;2Graduate University of Chinese Academy of Sciences,Beijing 100049,China;3Department of Cell Biology and Neuroscience,Rutgers University,Piscataway,NJ 08854,USA;4Synchrotron Radiation Laboratory,Institute of High Energy Physics,Chinese Academy of Sciences,Beijing 100049,China;5Department of Pharmaceutical Sciences,University of Maryland,Baltimore,MD 21201,USA;Copper ions influence the toxicity of β-amyloid(1-42) in a concen-tration-dependent manner in a Caenorhabditis elegans model of Alzheimer’s disease[J];Science China(Life Sciences);2011-06
7 ZHANG Lan1,2,LIU Fang1,3,WAN Sui-gui1,2,JIA Jian-ping1,2,LI Lin1,2(1.Department of Pharmacology,Xuanwu Hospital,Capital Medical University;2.Key Laboratory for Neurodegenerative Diseases,Ministry of Education;3.Department of Pharmacy,No.3 Hospital Affiliated to Beijing University;Alteration of Cytosolic Calcium in mtDNA-transferred Cells of Alzheimer's Disease[J];首都医科大学学报;2011-01
8 LIU Ying1,2,3,ZHANG Lan1,2,LI Ya-li1,2,LI Lin1,2(1.Department of Pharmacology,Xuanwu Hospital,Capital Medical University;2.Key Laboratory for Neurodegenerative Diseases,Ministry of Education;3.Department of Pharmacy,Beijing Children's Hospital,Capital Medical University;Effects of Icariin on α-synuclein Over-expression and Ubiquitin-proteasome System in Gene-transfected PC12 Cells[J];首都医科大学学报;2011-01
9 DING Yue-xia1,2,3,ZHANG Li1,2,YE Cui-fei1,2,WANG Wen1,2,LI Lin1,2(1.Department of Pharmacology,Xuanwu Hospital,Capital Medical University;2.Key Laboratory for Neurodegenerative Diseases,Ministry of Education;3.Department of Pharmacy,Yantai Yuhuangding Hospital,Yantai,Shangdong Province;Effects of Cornel Iridoid Glycoside on Hippocampal Neuron Survival and Apoptosis-regulating Factors in Fimbria-fornix Transected Rats[J];首都医科大学学报;2011-01
10 LI Xiao-li 1,2,YE Cui-fei2,ZHANG Li2,WEI Hai-feng 2,WANG Wen2,LI Lin2(1.The 3rd Affiliated hospital to Beijing University of Chinese Medicine;Beijing 100029,China;2.Department of Pharmacology,Xuanwu Hospital of Capital Medical University,Key Laboratory for Neurodegenerative Diseases of Ministry of Education,Beijing 100053,China);Cornel Iridoid Glycoside Improves Learning-memory Ability and Increases Expression of Neurotrophic Factors in Global Brain Ischemic Gerbils[J];中华中医药学刊;2011-02
【Secondary References】
Chinese Journal Full-text Database 8 Hits
1 LI Ying;WANG Yan-ru;ZHANG Xiao-qiang;WU Yun;DING Gang;WANG Zhen-zhong;XIAO Wei;Jiangsu Kanion Pharmaceutical Co., Ltd.;State Key Laboratory of Pharmaceutical New-tech for Chinese Medicine;;Effect of Epimedium brevicormon on Aβ_(25-35) induced SH-SY5Y cells injury[J];中草药;2017-24
2 YUAN Yu-jiao;TIAN Jin-zhou;SHI Jing;Department of Chinese Medicine,First People's Hospital of Dongcheng District,Beijing;No.3 Department of Encephalopathy,Dongzhimen Hospital,Beijing University of Traditional Chinese Medicine;;Transmission from the Moderate Degree to Mild Degree in 2 Years: A Case Report of Alzheimer's Disease[J];世界中西医结合杂志;2017-12
3 PENG A-xiang;HUANG Yuan-peng;Zhongshan Hospital,Xiamen University;;Thought of Bazhu Mixture treating on Alzheimer's disease[J];中华中医药杂志;2017-12
4 SHENG Wang;LI Xu-hua;HU Guo-Heng;LI Ying-chen;HOU Xiao-hua;ZOU Ting;WANG Xi-ao-ju;First Affiliated Hospital,Hunan University of Traditional Chinese Medicine;Hunan University of Traditional Chinese Medicine;;Impacts of Shennao Fuyuan Decoction on Learning Memory and Apoptosis Related Proteins in the Rat Models of Alzheimer's Disease[J];世界中西医结合杂志;2017-08
5 Huang Yan;Zhang Jing;Affiliated Hospital of Hainan Medical College;;Efficacy and safety of ginkgo biloba extract tablets combined with Butyphthalide on Alzheimer disease[J];中药药理与临床;2017-04
6 DONG Xiao-hong;YAO Zhuang;ZHANG Yan;LIU Hai-yang;ZHOU Zhong-guang;Jiamusi College,Heilongjiang University of Chinese Medicine;Heilongjiang University of Chinese Medicine;;Pharmacodynamic Substances of Waternut Herb for AD[J];中医药信息;2017-04
7 LUO Hong-bin;LIU Xiang-yu;MOU Nan-qiao;CHEN Wei;FAN Sha-sha;XIE Wen-zhi;SHANG Nan;YANG Chen-yu;XIE Feng-feng;CHEN Qin;WEI Zheng;Key Lab of Biologic Resources Protection and Utilization of Hubei Province;Dept of Biochemistry and Molecular Biology,Medical College;Institute of Neurological and Psychiatric Comorbidity,Hubei University for Nationalities;;Banqiao Codonopisis Pilosula improves cognitive dysfunction induced by high GSK-3β activity and its possible mechanism[J];中国药理学通报;2017-08
8 ZHAO Xia;DU Zhongrui;CHEN Wenfang;Department of Physiology,School of Basic Medicine,Qingdao University;;EFFECT OF ICARIIN ON INFLAMMATORY RESPONSE AND LEARNING AND MEMORY ABILITIES IN MICE WITH ALZHEIMER'S DISEASE[J];青岛大学医学院学报;2017-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved