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Influence of Permanent Occlusion of Bilateral Common Carotid Arteries onLearning and Memory Ability and Hippocampal Histomorphology in Rats

Liu Huibo Ye Cuifei Li Bin An Wenlin Li Lin(Department of Pharmacology,Capital Uinversity of Medica1 Sciences Xuan-Wu Hospita1,Beijing Key Laboratory of Brain Aging,Beijing 100053)  
Objective To investigate the cogenitive impairment and neuropathological damage in hippocam pus of rats following permanent occlusion of bilateral common carotid arteries(2OV).Methods The hippocampal histomorphology was observed and analyzed by an image processor,and learning and memory ability was tested using water maze.Results The time through all pathways in the water maze was prolonged and errors in passing the blind alleys obviously increased 30days after 2VO operation on rats.The learning and memory ability of the 2OV rats was still severely impaired and significant loss of the cells was observed in the CA1 subfield of hippocampus 60 days after the operation.Conclusions the progressive neuronal degeneration following the permanent 2OV is in part involved in chronic cerebral hypoperfusion induced long lasting deficits of learning and memory in rats.This animal models may be advantageous to the evaluation of drugs that prevent and treat vascular dementia.
【Fund】: 北京市科委资助
【CateGory Index】: R-332,R338.64
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