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《Chinese Journal of Health Care and Medicine》 2009-01
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Research on the changes of neurotransmitter in brain in patients with Parkinson's disease

HAN Yan,WANG Zhenfu,SUN Hong,CHEN Xianhong,CHEN Tong(Department of Neurology,Southern Building,PLA General Hospital,Beijing 100853,China)  
Objective To study the changes in the levels of neurotransmitter in brain in patients with Parkinson's disease(PD)by using encephalofluctuography technology,and investigate the effect of anti-Parkinsonian treatment on the activity of neuro-transmitter.Methods The changes of neurotransmitter were observed by using encephalofluctuography technology in 48 normal control cases and sixty-one cases of PD patients which came from the General Hospital of Chinese PLA during the period from Au-gust 2007 to December 2007.The patients underwent the assessment of the sub scale Ⅱ,Ⅲ and Ⅴof the Unified Parkinson's Dis-ease Rating Scale(UPDRS).Correlation analysis was made between the level of dopamine and UPDRS assessment.The changes of neurotransmitter were observed forty-eight hours after medication withdrawl and two hours after delivering benserazide.Results The level of dopamine in PD was significantly lower than of the control group(4.39±2.31,7.35±2.74,P0.01).Other neurotransmitters were no significant difference between the PD patients and control group.The level of dopamine of PD patients was negatively corre-lated with the UPDRS and the H Y range(r=-0.317,P=0.013;r=-0.430,P=0.001).Dopamine in PD patients increased significant-ly 1.5 hours after medicating benserazide as compared with that forty-eight hours after medication withdrawl(9.95±3.94,4.38±2.10,P0.01).Conclusions The level of dopamine decreases obviously in brain of the PD patients.The changes of neurotransmitter in brain can provide useful value for the diagnosis and therapy of PD.
【Fund】: 国家科技部十一五支撑计划(2006BAI04A11)
【CateGory Index】: R742.5
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Chinese Journal Full-text Database 2 Hits
1 Ying Jie Dai,Jun Fan,Zhao Yi Meng;Neurobiochemistrical character and progress of depression[J];Chinese Journal of Clinical Rehabilitation;2003-30
2 Wang Li min,Liu Zhong lin,Tao En xiang,Wang Li juan Wang Li min,Wang Li juan,Department of Neurology,Guangdong People's Hospital,Guangzhou 510080,Guangdong Province,China Liu Zhong lin,Tao En xiang,Department of Neurology,Second Affiliated Hospital,Sun Yat sen University,Guangzhou 510080,Guangdong Province,China;Changes of monoamine neurotransmitte levels in plasma in patients with Parkinson disease[J];Chinese Journal of Clinical Rehabilitation;2005-05
Chinese Journal Full-text Database 10 Hits
1 WU Mei-en (Department of Neurology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,China);Clinical nursing on the old Parkinson disease[J];Anhui Medical and Pharmaceutical Journal;2005-04
2 LI Tie shan, YAN Wen jing, LI Pei yuan\ (Department of Neurology, The Affiliated Hospital o f Qingdao University Medical College, Qingdao 266003, China)\;;AN OBSERVATION OF ELECTROP HYSIOLOGY IN PATIENTS WITH HEMIFACIAL SPASM[J];Acta Acadimae Qingdao Umvesitatis;2003-04
3 ZENG Qi-chang, HUANG Hong-xing, KUANG Wei-ping, et al. Department of Neurosurgery, Hunan Provincial Hospital of Brain Diseases, Changsha 410007, China;Treatment of Parkinson's Disease by Microelectrode-guided Thalamotomy and/or Pallidotomy: a Report of 225 Cases[J];Journal of Chinese Physician;2004-07
4 ZENG Shui-Lin~1,LI Tao~1,YANG Peng~1,KANG Xue-Jun~(2,3),XIAO Jing~2,HUANG Xiao~2,LIU Jun-Hua~1()~1Institute of Neurobiology,()~2School of Public Health,()~3State Key Laboratory of Molecular and Biomolecular Electronics,Southeast University,Nanjing 210009,China;Content changes of glutamic acid in striatum induced by lesion of ventral pallidum in rats with Parkinson's disease[J];Journal of The Fourth Military Medical University;2005-22
5 XU Jian (Department of Health Care of Cadre and Neurology, Affiliated Hospital of Guiyang Medical College,Guiyang 550004 ,China);A Clinial Study on the Treatment of Hemifacial Spasm, Blepharospasm and Meige Syndrome with Botulinum Toxin A[J];Journal of Guiyang Medical College;2002-01
6 ZHOU Jie , CUI Liping;Perioperative Nursing Care After Stereotaxis Operation for the Spastic Cerebral Palsy[J];Journal of Nursing Science;2006-24
7 Xu Nanyan Lu Weiliang Liu Hongying Department of nephrology hui zhou central hospital;Hui Zhou Guangdong 516080;Clinical Analysis of Essential Tremor(56 cases report)[J];China Foreign Medical Treatment;2008-09
8 HAN Yan, ZHANG Xiaohong, CHEN Tong, WANG Zhenfu, SUN Hong (Department of Neurology,Southern Building,PLA General Hospital,Beijing 100853,China);Survey of diagnosis and therapy in the Parkinson's disease[J];Chinese Journal of Health Care and Medicine;2008-01
9 HUANG Zuping, WANG Wei, LI Qiuyun,et al. Department of Radiology, The Second People's Hospital of Hunan Province,Changsha 410007, P. R. China;CT Findings in Parkinson's Disease and CT Analysis After Operation of Microelectrode Guided Thalamotomy and/or Pallidotomy[J];Journal of Clinical Radiology;2006-03
10 TAN Changlian,TU Ling,LUO Xuegang,et al. Department of Radiology,Second Xiangya Hospital,Central South University,Changsha,Hunan Province 410011,P.R.China;Study of 2D Chemical Shift Imaging in the Basal Ganglia of Parkinson's Disease[J];Journal of Clinical Radiology;2007-02
China Proceedings of conference Full-text Database 1 Hits
1 ;帕金森病早期诊断的中西结合方法探索[A];[C];2009
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 XIAO Hong YAO Hui GUO SHu-Wan LI Qi-Jun WU Ru-Jin(Department of Pharmaceutical Analysis, Chinese Pharmaceutical University, Nanjing 210009) (Nanjing Medical University Brain Hospital, Nanjing 210029);The Relationship Between the C825T Polymorphism of the G-Protein β 3 Subunit and Depression with SSRI,SNRI Treatment[J];The Chinese Journal of Clinical Pharmacology;2002-06
2 Xiao-Chen Si,Laboratory of Internal Medicine, Nanjing Univesity of Traditiona l Chinese Medicine, Nanjing 210029,Jiangsu Province,China Shakui Parvine,Keep Richrd F,Department of Surgery and Neurology,University o f Michigan, Ann Arbor,Michigan 48109-0532;Effects of 5-HT2c receptor antagonist on blood pressure and contract ility of the aortic rings in hypertensive rats[J];Modern Rehabilitation;2003-15
3 Bao Qiang Wei,Li Feng Niu,Dan Su,Staff Room of Diagnosis Fundamental Medical Institution of Liaoning Province, Shenyang 110101,Liaoning Province,China Ai Li Bao,Department of Chect,Benxi Municipal Central Hospital,Benxi 117000,Liaoning Province,China Kai Ming Li,Guang Xin Zhang,Pei Hong Cui,Xiao Ming He,Staff Room of Physiological Anatomy,Vocational Technical Institute,Liaoning University of Traditional Chinese Medicine,Shenyang 110005,Liaoning Province,China;Parkinson-like disease induced by Meperidine hydrochloride and concentration of the monoamine neurotransmitters in the midbrain of rats[J];Modern Rehabilitation;2003-16
4 ZHOU Xuan 1 ; WANG Xue qi 2 (1. Psychiatry and Health Subject 2000 Grade, 2.Dpartment of Neurobiology,Second Military Medical University, Shanghai 200433,China);Glutamate and γ-aminobutyric acid system in mood disorder[J];Chinese Journal of Neuroscience;2003-02
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