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《Chinese Journal of Health Care and Medicine》 2009-01
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Research on the changes of neurotransmitter in brain in patients with Parkinson's disease

HAN Yan,WANG Zhenfu,SUN Hong,CHEN Xianhong,CHEN Tong(Department of Neurology,Southern Building,PLA General Hospital,Beijing 100853,China)  
Objective To study the changes in the levels of neurotransmitter in brain in patients with Parkinson's disease(PD)by using encephalofluctuography technology,and investigate the effect of anti-Parkinsonian treatment on the activity of neuro-transmitter.Methods The changes of neurotransmitter were observed by using encephalofluctuography technology in 48 normal control cases and sixty-one cases of PD patients which came from the General Hospital of Chinese PLA during the period from Au-gust 2007 to December 2007.The patients underwent the assessment of the sub scale Ⅱ,Ⅲ and Ⅴof the Unified Parkinson's Dis-ease Rating Scale(UPDRS).Correlation analysis was made between the level of dopamine and UPDRS assessment.The changes of neurotransmitter were observed forty-eight hours after medication withdrawl and two hours after delivering benserazide.Results The level of dopamine in PD was significantly lower than of the control group(4.39±2.31,7.35±2.74,P0.01).Other neurotransmitters were no significant difference between the PD patients and control group.The level of dopamine of PD patients was negatively corre-lated with the UPDRS and the H Y range(r=-0.317,P=0.013;r=-0.430,P=0.001).Dopamine in PD patients increased significant-ly 1.5 hours after medicating benserazide as compared with that forty-eight hours after medication withdrawl(9.95±3.94,4.38±2.10,P0.01).Conclusions The level of dopamine decreases obviously in brain of the PD patients.The changes of neurotransmitter in brain can provide useful value for the diagnosis and therapy of PD.
【Fund】: 国家科技部十一五支撑计划(2006BAI04A11)
【CateGory Index】: R742.5
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