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《Chinese Journal of Health Care and Medicine》 2009-02
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Experimental study on effect of shenqi decoction on matrix metalloproteinases-9 expression of pulmonary carcinoma mice

WANG Zhikuan,CHEN Liping,JIAO Shunchang(Department of Medical Oncology,Department of TCM,South Building,PLA General Hospital,Beijing 100853,China)  
Objective To study the effect of Shenqi decoction on matrix metalloproteinases-9 expression of pulmonary car-cinoma mice and to explore the mechanism of its prohibiting influence on recurrence and metastasis of tumour.Methods Sixty T739 mice were equally divided into 3 groups according to principle of similar weight:western medicine chemotherapy group,herbs treatment group and bearing cancer control group.The western medicine chemotherapy group were treated by intraperitoneal injection of CTX for 5 days.The herbs treatment group were given Shenqi decoction through gastrogavage for 21 days.22 days later,the mice of each group were killed.The dynamic express of matrix metalloproteinases-9 expressions in lung tissue was respectively assessed using the immuno-hisochemical technique.Results Shenqi decoction can improve the general condition of the mice.Compared with bearing cancer control group,the expression of MMP-9 in the lung tissue of herbs treatment group was decreased significantly(P0.05).Conclusions Shenqi decoction can significantly decrease the expression of MMP-9 in the lung tissue of carcinoma mice.It suggested that Shenqi decoction can prohibit recurrence and metastasis of tumour.
【Key Words】： Lung cancre Matrix metalloproteinases-9 Shenqi decoction Recurrence and metastasis of tumour
【CateGory Index】： R285.5;R734.2
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