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《Pharmaceutical Journal of Chinese People's Liberation Army》 2001-05
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Inhibitory Effect of Puerarin on Oxidative Modification of Low Density Lipoprotein

ZHU Qing Lei ①,GAO Wei Hai ②,LU Xin Ran ③ ( ① Institute of Geriatric Cardiology,General Hospital of PLA,Beijing 100853)( ② Department of Medicament,Sishui Hospital of Traditional Chinese Medicine,Sishui 273200,Shangdong) ( ③ Applied Pha  
Aim To study the inhibitory effect of Puerarin (Pue) on oxidative modification of low density lipoprotein (LDL).Methods LDL extracted by sedimentation was oxidatively modificated by ultraviolet ray (uv) irradiation and copper sulfate.Effect of Pue on the oxidative modification of LDL was observed,using vitamin E (Vit E) as control.Results Pue (0.01~1.0mmol·L -1 ) concentration dependently inhibited the increase of malonadehide bis (MDA) of LDL induced by uv irradiation and copper sulfate as well as with Vit E of 0.1mmol·L -1 .Conclusion It is suggested that the oxidative modification of LDL could be inhibited by Pue.
【CateGory Index】: R285
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