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《Pharmaceutical Journal of Chinese People's Liberation Army》 2003-06
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Immunopotentiating Effect of Morinda Officinalis Oligosaccharides

XU Chao-Dou ②,ZHANG Yong-Xiang,YANG Ming ③ ( ②Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850 China) ( ③The United Laboratories LTD,Zhuhai 519095,Guangdong China)  
Aim To study the immunopotentiating effect of Morinda officinalis oligosaccharides(MOO) in mice.Methods Lymphocyte proliferation and antibody production response were employed to evaluate the effect of MOO on the immune response.Results Oral administration of MOO 25,50mg·kg -1 significantly promoted splenocyte proliferation and antibody production response.MOO 25~200μg·ml -1 had no effect on splenocyte proliferation and Peyer's patches cells proliferation in vitro.Conclusion MOO could potentiate the immuneological function in mice,but the immunopotentiating effect of MOO are not achieved by a direct potentiating effect on immunocompetent cells.
【Fund】: 国家自然科学基金重点项目 No .3 973 0 480
【CateGory Index】: R285
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