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《Pharmaceutical Journal of Chinese People's Liberation Army》 2004-01
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The Effects of Aloe and Its Compound on Lipid Peroxidation and Certain Cytokines of Aging Mice

WANG Zhong,GU Shun-Cai,HAN Yan-Li,XIAO Ai-Zhen,XIN Yi-Mei,HAO Ai-Gong,QI Ying,CHENG Jie,ZHENG Wei (Institute of Aviation Medicine,Air Force,Beijing 100036 China)  
Aim To observe the anti-aging effects of aloe and its compound on anti-lipid peroxidation and regulating certain cytokines so as to explore its potential application in geriatrics as an anti-aging drug.Methods Forty-eight Kunming mice were randomly divided into four groups.The three aging-model groups were made by D-galactose,of which two groups were gavaged with pure aloe liquid and its compound respectively.The groups of aging control and normal control were gavaged with equal amount of 0.9% NaCl solution.The aloe and its compound were given to the mice daily for 28 days.The concentration of malon dialdehyde (MDA),the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in blood and the levels of IL-1?IL-6?IL-8 in serum were examined.Results Compared to the normal control,the aging mice showed significant increase in the concentrations of MDA in blood and significant decrease in the activities of SOD,GSH-Px in blood and the levels of IL-1?IL-6?IL-8 in serum as well as weight loss.The aging groups taking aloe and its compound showed significant improvement for the above parameters compared with the group without taking them.The differences were statistically significant.Conclusions Aloe and its compound showed anti-lipid-peroxidation, enhanced elimination of free radicals and increase of reduced IL-1?IL-6?IL-8 levels in experimental aging mice.
【CateGory Index】: R285
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