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《Pharmaceutical Journal of Chinese People's Liberation Army》 2005-01
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Immunopotentiating Effect of Soybean Oligosaccharides

XU Chao-Dou ①,LIANG Ai-Jun,ZHU Ye ②,TAO Shen-Yuan ( ①Institute for Drug and Instrument Control Health Dept,GLD of PLA,Beijing 100071 China) ( ②Medical Library of PLA,Beijing 100039 China)  
Aim To study the immunopotentiating effect of Soybean oligosaccharides(SBOS) in mice.Methods Lymphocytes proliferation and antibody production response were employed to evaluate effect of SBOS on the immune response.Results Oral administration of SBOS 10,20mg·kg -1 for 7 days significantly promoted splenocytes proliferation and the number of antibody forming cells (PFC) in normal mice,SBOS could ameliorated the low proliferation of spleen lymphocytes and the antibody production response in SAM and S 180 treated mice.SBOS 25~200μg·ml -1 had little effect on splenocytes proliferation and Peyer’s patches cells proliferation in vitro.Conclusion SBOS could potentiate the immuneological function in normal mice and immunodeficient mice,but the immunopotentiating effect of SBOS are not achieved by a direct potentiating effect on immunocompetent cells.
【CateGory Index】: R285
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