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《Pharmaceutical Journal of Chinese People's Liberation Army》 2005-01
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Methods Study on the Model of Chemical Hepatic Injury ①

HUANG Zheng-Ming ②,YANG Xin-Bo,CAO Wen-Bin,CHEN Hong-Yan,LI Zhuang ③ ( ②Department of Phamarcology,302 Hospital Pharmaceutic,Beijing 100039 China) ( ③Institute of geriatrics chinese PLA general hospital,Beijing 100853 China) ( ④Department of Virology,Institute of Medical Biotechnology,Chinese Academy Sciences,Beijing 100500 China)  
Aim In basis of classical model to explore and improve many experimental model of chemical hepatic injury in order to provide varies methods for application study on drugs of prevention and cure hepatitis B.Methods The elementary study markers were the changes of blood biochemistry,liver function and liver histology.The model of hepatic injury was induced by chemical hepatic toxicity(CCl 4,D-Gala,ANIT),immunity hepatic injury was induced by BCG vaccine and lipopolysaccharide (LPS).Results According to the disorder of hepatitis B and character of hepatitis B infection,many models were set up.They are animal models of jaundice and high transaminase induced by chemical agents which was similar to hepatitis B,the models of immunity hepatic injury induced by BCG and LPS respectively.Conclusing The established experimental models of chemical hepatic injury,which are similar to that of hepatitis B,are stable and can be repeated easily.
【Fund】: 国家科技部“九·五”科研基金项目 No .96-90 1-0 5 -0 16
【CateGory Index】: R575
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