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《Pharmaceutical Journal of Chinese People's Liberation Army》 2005-03
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The Preparation and Characteristics of Fluorouracil Nanoemulsion

YANG Qing-Yan~②,WU Dao-Cheng~③,WU Hong,FENG Ai-Ling(~②Department of Chemistry,the Fourth Military Medical University,Xi'an 710032,Shanxi China)(~③Department of Biomedical Engineering,Xi'an Jiaotong University,Xi'an 710038 Shanxi China)  
Aim To study the Fluorouracil soybean oil nanoemulsion phase diagrams,stability,and release characteristics in vitro.Methods Based on the triangular phase diagram,the optimal formulation of the nanoemulsion was investigated.The diameter of fluorouracil nanoemulsion was determined by Transmission Electron Microscope(TEM) method.The concentration and the release characteristics of fluorouracil nanoemulsion in vitro were measured by HPLC.Result Fluorouracil nanoemulsion was spherical in shape,its diameter was 20±10nm,the encapsulation of Fluorouracil in nanoemulsion was 85.06%,50% of the drug was released after 11 hours,95% of the drug was sustained to release in 50 hours.Conclusion The nanoemulsion is stable and homogeneous.Its sustained release characteristics are significant existed.
【Fund】: 国家自然科学基金资助项目 No.30170271;30300456
【CateGory Index】: R943
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