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《Pharmaceutical Journal of Chinese People's Liberation Army》 2005-06
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Comparison of Antiviral Effect of Different Extracts from Radix Isatis by Biothermodynamics①

ZHAO Yan-Ling ②③,XIAO Xiao-He,HU Yan④,LIAO Qing-Wen,WANG Jia-Bo,MO Pan-Yong④ (②Institute of Chinese Medicine,302 Hospital of PLA,Beijing 100039 China) (③Academy of Military Medical Sciences,Beijing 100850 China) (④Department of Virology,Institute of Infectious Diseases,302 Hospital of PLA,Beijing 100039 China)  
Aim To study and analyze antiviral effects of different extracts from Radix Isatis based on the combination of thermodynamics and common cell culture in vitro.Methods Antiviral effects of extracts from Radix Isatis were observed by thermocalrimetry on hela cells transfected by mumps virus,and at the same time were evaluated by conventional pharmacological experiments.Results The general extracts,EtOAc extracts,nBuOH extracts,CHCl3 extracts and P.E.extracts had antiviral effects to some extent while the residue after extracting did not.The comparison of their antiviral activities was as follows:EtOAc extracts nBuOH extracts CHCl3 extracts general extracts P.E.extracts.The results were consistent with those of the common pharmacological experiments.Conclusion From the results of this experiment,the anti-virus screening method based on biothermodynamics was established tentatively.
【Fund】: 国家中医药管理局面上项目 No.0405ZP70
【CateGory Index】: R285
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