Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Pharmaceutical Journal of Chinese People's Liberation Army》 2007-03
Add to Favorite Get Latest Update

Effects of Breviscapine on Learning and Memory Dysfunction of Rats Induced by Traumatic Brain Injury

MAO Jun-Qing①,QIU Yan②,LI Tie-Jun②,RUI Yao-Cheng②,ZHANG Wei-Dong③(①Department of Pharmacy,Hospital 85 of PLA,Shanghai 200053 China)(②Department of Pharmacology,③Chemistry of Natural Medicine College of Pharmacy,Second Military Medical University,Shanghai 200433 China)  
Aim To study the effects of breviscapine on cognitive function after traumatic brain injury(TBI)in rats.Methods Rat traumatic brain injury was made by fluid percussion brain injury method.The learning and memory function was evaluated using the Morris water maze test and passive avoidance test.Total superoxide dismutase(T-SOD)and malondialdehyde(MDA)in brain tissues were measured after the cognitive function test.Results Breviscapine can significantly shorten the escape latent period of TBI rats in Morris water tests,extend the latent period of learning and memory of TBI rats and decrease the frequency of errors in passive avoidance tests.Breviscapine significantly decreased MDA content and increased T-SOD content in brain tissues.Conclusion Breviscapine can improve cognitive dysfunction after TBI in rats,and its protective effect was related to the decreasing oxidative stress in brain tissues.
【CateGory Index】: R285
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved