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《Pharmaceutical Journal of Chinese People's Liberation Army》 2007-04
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Studies on the Chemical constituents of the Root of Angelica pubescens f. biserrata

ZHANG Cai-Yu②③,ZHANG Ben-Gang,YANG Xiu-Wei④(②Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100094 China)(③National Institute for the Control of Pharmaceutical and Biological Products,Beijing 100050 China)(④The State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing 100083 China)  
Aim To study the chemical constituents of the root of Angelica pubescens Maxim.f.biserrata Shan et Yuan in the China National GAP Base of Chinese Materia Medica for Angelica pubescens Maxim.f.biserrata in Hubei Province of China.Methods The chemical components were isolated by solvent extraction and column chromatography and their structures were identified on the basis of physic-chemical constants and spectral data.Results Thirteen compounds were isolated and identified as osthole(Ⅰ),columbianadin(Ⅱ),2'-deoxymeranzin hydrate(Ⅲ)、columbianetin acetate(Ⅳ),bergapten(Ⅴ),xanthotoxin(Ⅵ),bergaptol(Ⅶ),columbianetin(Ⅷ),sucrose(Ⅸ),isoimperatorin(Ⅹ)、psoralen(Ⅺ),bisabolangelone(Ⅻ)and glyceride(ⅩⅢ).Conclusion Compounds Ⅶ and Ⅺ were isolated from the titled plant and Ⅲ from genus Angelica for the first time
【Fund】: 国家自然科学基金资助项目 No.30672609
【CateGory Index】: R284
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