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《Pharmaceutical Journal of Chinese People's Liberation Army》 2008-05
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The Formulation of Betulinic Acid Microemulsion

DONG Jiao①,XIN Yi-Mei②,XIAO Ai-Zhen②,WANG Zhen-Guo②(①The General Staff Management and Safegard Deparment Hospital,Beijing 100082 China)(②Air Force Institute of Aviation Medicine,Beijing 100036 China)  
Aim To prepare and evaluate betulinic acid microemulsion.Methods The formulation was investigated by pseudoternary phase diagram obtained by titration method.The determination method of betulinic acid was established by HPLC.The solubilization of the microemulsion on betulinic acid was experimented,and the stability of the microemulsion after being placed under the condition of room temperature,40℃,or illumination for 10 days was evaluated.Results Both Cremophor RH 40 and Tween80 were main formulation of the microemulsion.The size of microemulsion increased with Km(the weight ratio of surfactant to ethanol).Oil phase formulation containing IMP or IPP had little effect on the size of the microemulsion.The microemulsion placed under the condition of room temperature,40℃,or illumination for 10 days was stable.Conclusion The optimum formulation was as follows:tween80-ethanol-IPM-water=5∶ 5∶ 3∶ 8.6.
【CateGory Index】: R94
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