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《Pharmaceutical Journal of Chinese People's Liberation Army》 2009-06
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Effects of Rubiadin from Morinda officinalis on Osteoclastic Bone Resorption

BAO Lei-Lei①②,QIN Lu-Ping,BIAN Jun②,JIAO Lei,WU Yan-Bin,HAN Ting,ZHANG Qiao-Yan (①Department of Pharmacognosy,School of Pharmacy,Second Military Medical University,Shanghai 200433 China) (②No.411 Hospital of PLA,Shanghai 200434 China)  
Aim To investigate the cellular mechanism of rubiadin inhibitory effects on bone resorption.Methods Multinucleated osteoclasts were induced by 1,25-dihydroxyvitamine D 3 and dexamethasone from bone marrow cells and cocultured with primary osteoblastic cells.The activity of TRAP was measured by p-nitrophenyl sodium phosphate assay.The bone resorption pit area on the bone slices formed by osteoclast was measured by computer image processing.The cathepsin K was measured by fluorescence microplate reader.Results At the concentration of 0.1,1 and 10μmol · L-1,rubiadin dose-dependently suppressed the formation of TRAP-positive multinucleated cells,the TRAP activity and the osteoclastic bone resorption.Conclusion Rubiadin can decrease bone loss through the inhibition of osteoclast formation,differentiation and bone resorption.
【CateGory Index】: R285.5
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【References】
Chinese Journal Full-text Database 2 Hits
1 GUO Yuan-hui;XUE Li-ming;NIE Yan;WANG Ying;ZHAO Lu;QIN Lu-Ping;ZHANG Qiao-yan;YU Yuan;School of Pharmacy,Second Military Medical University;Department of Pharmacy,Fujian University of Traditional Chinese Medicine;;Effect of icariin and curculigoside on inhibition of osteoclastic formation,differentiation and bone absorption[J];Journal of Pharmaceutical Practice;2013-04
2 ZHENG Suyu,CHEN Jian,HE JianQuan,et al.Department of Rehabilitation,the Affiliated Zhongshan Hospital of Xiamen University,Xiamen 361004,China;Effect of morinda officinalis-containing serum on the expression of CAⅡ and NFAT2 mRNA in osteoblast-osteoclast co-culture system[J];Chinese Journal of Osteoporosis;2013-02
【Citations】
Chinese Journal Full-text Database 4 Hits
1 Liu Zude;Zang Hongsheng;Ouyang Yueping(Department fo Orthopaedic,Institute of Traumatic Surgery,The Second Military Medical University,Shanghai);BIOLOGICAL STUDY OF GROWTH PATTERN OF NEWBORN RAT CALVARIA OSTEOBLASTIC CELL IN VITRO[J];ACTA ANATOMICA SINICA;1995-02
2 WANG Lin, MAO Yu-jia, WANG Wen-jie~ * (Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China);Inhibitory effect of diacerein on osteoclastic bone destruction and its possible mechanism of action[J];Acta Pharmaceutica Sinica;2006-06
3 YUAN Shan-qin,ZHAO Yi-min~*(Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850,China);Chemical constituents of Knoxia valerianoides[J];Acta Pharmaceutica Sinica;2006-08
4 LI Nan,WANG He-ming,GUO Su-hua,LIN Xu,ZHENG Liang-pu,WANG Li.Department of Orthopaedics and Traumatology,Fujian College of TCM,Fuzhou 350108,Fujian,China;Protection of apoptosis of osteoblast cultured in vitro by Morinda Root Polysaccharide[J];China Journal of Orthopaedics and Traumatology;2008-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LI Nan1 WANG He-ming1 GUO Su-hua1 ZHENG Liang-pu2 WANG Li1(1Fujian college of TCM,Fuzhou 350108,China;2Academy of integrative medicine,Fujian college of TCM,Fuzhou 350108,China);Effect of Radix Morindae Officinalis polysaccharide on expression of Cbfα1 mRNA in osteoblast cultured in vitro[J];China Journal of Traditional Chinese Medicine and Pharmacy;2007-08
2 LING Kun1,ZHAO Yi2,GUO Su-hua3 (1Sports Department of Fujian University of TCM,Fuzhou 350108,China;2Orthopedics and Trumatology Department of Fujian University of TCM,Fuzhou 350108,China;3Zhangzhou Vocational college of Health,Zhangzhou 363000,China);Effect of medicated serum of Radix Morindae Officinalis on skeletogenous cell bionomics[J];China Journal of Traditional Chinese Medicine and Pharmacy;2010-06
3 ZHANG Qiao Yan 1, QIN Lu Ping 1* , TIAN Ye Ping 2, ZHENG Han Chen 1, HUANG Mao 3, LIU Zu De 4 (1. Department of Pharmacognosy, College of Pharmacy, Second Military Medical University, Shanghai 200433, China; 2. Department of Immunology, Dep;Effect of osthole on osteoblasts in neonatal rat calvarial cultures[J];Academic Journal of Second Military Medical University;2000-10
4 WU Ling-feng,ZENG Ling-jie(School of TCM,Guangdong Pharmaceutical University,Guangzhou 510006,China);Chemical constituents from the roots of Morinda officinalis and the quality control[J];Journal of Guangdong Pharmaceutical University;2012-01
5 ZHANG Hua-lin1,WANG Dong-mei2,YANG Hong-yan1,ZHOU Zhong-liu1,LIN San-qing1,XIA Jing-min1(1.Chemistry Science and Technology School,Zhanjiang Normal University,Zhanjiang 524048,China)(2.School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 5100006,China);Study on Decolorization and Deproteinization Process of Polysaccharides from Morinda officinalis How by Resin Adsorption[J];Modern Food Science and Technology;2012-12
6 ZENG Xiao-qian,ZHANG Er-mei,PAN Kui-you,YANG Xiao-hong,CHEN Hua-xiao,SHAO Mei-yun,ZHANG Hua-lin(Chemistry Science and Technology School,Zhanjiang Normal University,Zhanjiang 524048,China);Extraction of Polysaccharides from Morinda officinalis How Residue[J];Modern Food Science and Technology;2013-05
7 LI Yunhai;WANG Yafei;WEI Zhiqiang;ZHANG Qingfeng;JIANG Zhuonan;BAI Liqun;Eastern Orthopaedic Hospital of Beijing University of Traditional Chinese Medicine;;Advances in experimental research of morinda officinalis on bone metabolism[J];China Medicine and Pharmacy;2013-22
8 HUANG You-lin1,GUO Su-hua2,ZHAO Yi2(1.Fujian Institute for Drug Control,Fuzhou 350001,China;2.Department of Pharmacy,Fujian University of Traditional Chinese Medicine,The Key Laboratory of Chinese Pharmacies for Fujian University of Traditional Chinese Medicine of Fujian Higher Education,Fuzhou 350108,China);Preliminary study on the proliferation effect on bone marrow mesenchymal stem cells of constituents from radix morindae officinalis produced in Fujian province[J];Strait Pharmaceutical Journal;2007-10
9 ZHU Xing-yi,GUO Qiao-feng,WU Xue-ling,SU Wei-ke(Key Laboratory of Pharmaceutical Engineering of Ministry of Education,College of Pharmaceutical Science,Zhejiang University of Technology,Hangzhou 310014,China);A New Method of Synthesizing Diacerhein[J];Chinese Journal of Synthetic Chemistry;2010-02
10 WANG Zhao-hong,ZENG Tao.Sichuan Guangyuan Food and Drug Inspection and Testing Office,Guangyuan 628000,China;Emperimentcal study of advancement of Chinese kidney-tonifying drugs for treating osteoporosis[J];Global Traditional Chinese Medicine;2011-03
China Proceedings of conference Full-text Database 3 Hits
1 WANG Zhao-hong1,ZENG Tao2 (1.Guangyuan Institute for Food and Drug Control of Sichuan province,Guangyuan,Sichuan,china,628000 ;2.Guangyuan prison hospital of Sichuan Provice,Guangyuan,Sichuan,china,628019);Emperimentcal study of advancement of Chinese kidney-tonifying drugs for treating osteoporosis[A];[C];2011
2 BAO Lei-Lei1,2,Bian Jun1,ZHANG Qiao-Yan2,Qin Lu-Ling2,Yuan Bing1 (1 NO.411 Hospital of PLA,Shanghai 200434,China ;2 Department of Pharmacognosy,School of Pharmacy,Second Military Medical University,Shanghai 200433,China );Effects of 2-hydroxymethyl-3-hydroxy-anthraquinone from Morinda officinalis on Osteoclastic Bone Resorption[A];[C];2010
3 ;Morinda profile and its research progress[A];[C];2009
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 FAN Li,LI lin,HE Hui-feng(Department of Dermatology,Sichuan Provincial People's Hospital,Sichuan Academy of Medical Sciences,Chengdu 610031,China);Pharmacological studies on anti-inflammatory and analgesic effects of radix angelicae pubeascentis's volatile oil[J];Anhui Medical and Pharmaceutical Journal;2009-02
2 CAI Hui,YAO Ru-bing,GAO Pei-fang(Department of Integrated Traditional Chineseand Western Medicine,Nanjing General Hospitalof Nanjing Military Command,PLA,Nanjing,Jiangsu 210002,China);Effects of MTX on the proliferation of rheumatoid arthritis' circum-citrullinated peptide antigen special T cell[J];Anhui Medical and Pharmaceutical Journal;2010-07
3 CAI Jing,XU Jian-hua,LIAO Zhuo-jun,LIAN Li(Dept of Rheumatology and Immunity,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,China);Relationship between the single nucleotide polymorphisms of transporters genes and the efficacy and toxicity of methotrexate in rheumatoid arthritis patients[J];Anhui Medical and Pharmaceutical Journal;2010-11
4 LIU Jian (The First Affiliated Hospital, Anhui College of Traditional Chinese Medicine, Anhui Hefei 230031, China);Research on the Treatment of Rheumatoid Arthritis Based on Spleen[J];Journal of Anhui Traditional Chinese Medical College;2004-01
5 GUO Jun-hao,ZHANG Yong-wen,ZHAO Zhi-ming,YAO Ru-bing,SHANG Wei,ZANG Xu-li,WEI Qun-li,CAI Hui(Department of Integrated Traditional Chinese and Western Medicine,Nanjing General Hospital of Nanjing Military Command,PLA,Jiangsu Nanjing 210002,China);Effects of Bushen Kangsong Pellet on Bone Mineral Density in Postmenopausal Osteoporosis[J];Journal of Anhui Traditional Chinese Medical College;2008-05
6 YAO Ru-bing,GAO Pei-fang,CAI Hui(Department of Integrated Traditional Chinese and Western Medicine,Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing Jiangsu 210002,China);Effects of methotrexate on the secretion of interferon-γ and interleukin-4 by rheumatoid arthritis′ circum-citrullinated peptide antigen specific T cell[J];Journal of Bengbu Medical College;2011-01
7 Chan Meiying,Cheng Huijuan,Le Hongxia (Department of Microbiology,Anhui College of Tradiltional Chinese Medicine,Hefei);SUSCEPTIBILITY TESTING OF GARDNERELLA VAGINALIS TO TRADITIONAL CHINESE MEDICINES[J];ACTA ACADEMIAE MEDICINAE BENGBU;1995-04
8 Lou Yufang TCM Hospital of Shengzhou City, Zhejiang Province(312400);Paralysis Treated by Kidney[J];Journal of Zhejiang University of Traditional Chinese Medicine;2007-03
9 HUANG Tao1,ZHANG Gang-lin1,LI Nan2(1.Beijing Sport University,Beijing 100084 China;2.Fujian College of Traditional Chinese Medicine,Fuzhou 350108,Fujian China);The Influence of Morida Officinalis How Polysaccharide on the Apoptosis of Rabbit Chondral Cell Incubated Exosomatically[J];Journal of Beijing Sport University;2010-08
10 ZHONG Lu, CHEN Fang-yuan, WANG Hai-rong, WANG Cheng, OUYANG Ren-rong. Department of Hematology, Renji Hospital, the Second Medical University, Shanghai 200001, China;Effects of quercetin on cell morphology and expression of VEGF in K562 cell[J];Journal of Leukemia & Lymphoma;2006-03
【Secondary References】
Chinese Journal Full-text Database 5 Hits
1 LI Yunhai;WANG Yafei;WEI Zhiqiang;ZHANG Qingfeng;JIANG Zhuonan;BAI Liqun;Eastern Orthopaedic Hospital of Beijing University of Traditional Chinese Medicine;;Advances in experimental research of morinda officinalis on bone metabolism[J];China Medicine and Pharmacy;2013-22
2 Chen Yan;Xiao Xiaojin;Bao Xiaping;Zhang Lihong;Zeng Dezhen;Li Xiaodong;Liu Xianxiang;College of Pharmacy,Fujian University of Traditional Chinese Medicine;Xiamen Traditional Chinese Medicine Co. ,Ltd.;Key Lab on Senile Diseases of Integrative Institute of Fujian Province;;Analgesia and Anti-inflammatory Effects of Tougu Xiaotong Prescription[J];China Journal of Chinese Medicine;2013-11
3 SU Junxia;XU Jun;LI Jianhua;Department of Nephrology,First Hospital of Lanzhou University;;Effects of Compound Sevenlobed Yam Rhizome Soup on NGAL and KIM-1 in Urine of Uric Acid Nephropathy Rats[J];Chinese Journal of Integrated Traditional and Western Nephrology;2014-03
4 You Tao;Wang Lu;Ji Yan;Wu Xiao-hong;Department of Prosthodontics,the Affiliated Hospital of Stomatology,Chongqing Medical University;Chongqing Key Laboratory of Oral Diseases and Biomedical;;Naringin intervention influences the formation and function of osteoclasts from mouse calvarial bone[J];Chinese Journal of Tissue Engineering Research;2013-37
5 CHEN Hong;CHEN Min;HUANG Ze-hao;LIN Yue-zhen;College of Pharmacy,Fujian University of T Chinese Medicine;;Chemical Constituents of Morinda officinalis[J];Chinese Journal of Experimental Traditional Medical Formulae;2013-21
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 LI Nan1 WANG He-ming1 GUO Su-hua1 ZHENG Liang-pu2 WANG Li1(1Fujian college of TCM,Fuzhou 350108,China;2Academy of integrative medicine,Fujian college of TCM,Fuzhou 350108,China);Effect of Radix Morindae Officinalis polysaccharide on expression of Cbfα1 mRNA in osteoblast cultured in vitro[J];China Journal of Traditional Chinese Medicine and Pharmacy;2007-08
2 WANG He ming,WANG Li,LI Nan(Orthopaedic and Traumatology department of FCTCM,Fuzhou,Fujian 350003, China);Study the Influence of Morinda Officinalis How on the Differentiation from Marrow Stroma Cell to Osteoblast[J];Journal of Fujian College of Traditional Chinese Medicine;2004-03
3 GUO Su-hua,WANG He-ming,HUANG Tao,et al(Fujian College of Traditional Chinese Medicine,Fuzhou,Fujian 350108,China);Determination of Polysaccharide from Morinda officinalis How in Nanjing[J];Journal of Fujian College of Traditional Chinese Medicine;2006-01
4 LI Fei-Fei WU Yong-Jun QU Ling-Bo WU Yi-Ming (Department of Chemistry,Zhengzhou University,Zhengzhou 450052,P. R. China) (College of Public Health,Zhengzhou University,Zhengzhou 450052,P. R. China);Study on Anti-Radical Activity of Chinese Medicine Morinda Officinal is How[J];Chinese Journal of Spectroscopy Laboratory;2005-03
5 WU Yong-jun~1, SHI Jie~2, QU Ling-bo~2, LI Fei-fei~2, LI Xiao-jing~2, WU Yi-ming~ 1 1. College of Public Health, Zhengzhou University, Zhengzhou 450052, China 2. Department of Chemistry, Zhengzhou University, Zhengzhou 450052, China;Determination of Antioxidation of the Extract from Chinese Medicine Morinda Officinalis How by Flow Injection Chemiluminescence and Spectroscopy[J];Spectroscopy and Spectral Analysis;2006-09
6 CHENZhong,DENG Hui-zhen,MO Qi-lin,LI Zhong-wen(Department of Biology, Hainan Normal University, Haikou 571158,China);Determination of the contents of valuable compositions of Morinda officinalis How in different regions and analysis of its protection for the liver[J];Journal of Hainan Normal University(Natural Science);2003-04
7 XU Chao-Dou ②,ZHANG Yong-Xiang,YANG Ming ③ ( ②Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850 China) ( ③The United Laboratories LTD,Zhuhai 519095,Guangdong China);Immunopotentiating Effect of Morinda Officinalis Oligosaccharides[J];Pharmaceutical Journal of Chinese People's Liberation Army;2003-06
8 CAI Bing~②,CUI Cheng-Bin,CHEN Yu-Hua,XU Yu-Kun,LUO Zhi-Pu,YANG Ming,YAO Zhi-Wei,ZHAO Yi-Min (Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850 China);Evaluation of Antidepressant Effect of Ba Ji Tian,a Traditional Chinese Medicine from the Roots of Morinda officinalis How,in Mouse and Rat Models[J];Pharmaceutical Journal of Chinese People's Liberation Army;2005-05
9 XU Guoping~(1,2),ZHANG Chunni~2,WANG Junjun~2,ZHOU Yu~2,Liu Qi~2,LI Ke~2,ZHANG Shuangquan~1(1.Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology,Life Science College,Nanjing Normal University,Nanjing 210097;2.Department of Medical Laboratory Science,Nanjing General Hospital,Nanjing 210002,China);Inhibitory effect of RRTJ and NoniJ on growth of human ovarian cancer cells[J];Chinese Journal of Clinical Laboratory Science;2006-02
10 LIU Wen-wei,GAO Yu-qiong,LIU Jian-hua,HUO Xin,YANG Nai-jia(Guizhou Institute of Biotechnology Research and Development,Guiyang 550002,P.R.China);Determination of Chemical Constituents of the Volatile Oil from Radix morindae officinalis[J];Biotechnology;2005-06
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