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《Pharmaceutical Journal of Chinese People's Liberation Army》 2014-06
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Field Study on Pahax notoginseng Tablets Improving Operational Capability in Human Body at High Altitude

CUI Jian-hua;GAO Liang;ZHANG Gang;LI Nian-hua;WANG Yang;YANG Sheng-hong;LI Bin;WANG Fu-ling;Research Center of High Altitude Disease,Hospital 18 of PLA;College of High Altitude Military Medicine,Third Military Medical University,Key Laboratory of High Altitude Medicine,Ministry of Education,The Key Laboratory of High Altitude Physiology and High Altitude Disease,PLA;  
Objective To explore the effect pahax notoginseng tablets on physical work capacity of the militarg at high altitude.Methods 40 young people were respectively chosen and randomly divided into 2 groups(pahax notoginseng tablet group,n = 20;and control group,n = 20) at an altitude of 3700 m and 5100 m.The two groups were given oral pahax notoginseng tablets and placebo respectively,twice a day for 15 days.The physique index of exercise of the two groups was messured according to the National Military Criteria(GJB1337-92)pre-and post-treatment while their blood samples were collected and the level of ALT,AST,TB,DB,NO,NOS,SOD,MDA,BLA and BUN was measured.Results(1) 3700 m:Compared with pre-treatment,the PWC170 and the step index were raised while the HR of the first-level and secoud-level load was reduced(P 0.05 or P 0.01),compared with control group(post-treatment),VO2 max,index of step was raised,while the HR of the first-level and secoud-level load was reduced(P 0.05 or P 0.01).Compared with pre-treatment,the level of ALT,AST,TB,DB,BUN and BLA was reduced,but the level of SOD,NO and NOS was increased(P 0.05 or P 0.01),compared with control group(post-treatment),the level of AST,TB,DB and BUN was reduced while the level of SOD was increased(P 0.05 or P 0.01).(2) 5100 m:Compared with pre-treatment,PWC170 and the step index and Sa O2 were increased while the HR of the first-level load was reduced(P 0.05 or P 0.01).Compared with control group(post-treatment),the HR of the first-level load was reduced(P 0.05).Compared with pretreatment,the level of ALT,AST,TB,DB and MDA was reduced while the level of NOS was increased(P 0.05 or P 0.01).Compared with control group(post-treatment),the level of AST,TB,DB,MDA and BLA was reduced(P 0.05 or P 0.01).Conclusion Pahax notoginseng tablets have anti-fatigue and anti-hypoxia effect,improve exercise performance of the human body,and alleviate damage to organs under hypoxic conditions.
【Fund】: 国家科技支撑计划项目 No.2009BAI85B06;; 高原医学教育部重点实验室资助项目 No.2011JSGY05
【CateGory Index】: R82
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