EFFECT OF ANISODAMINE ON CHANGES IN CALCIUM AND CALMODULIN CONTENTS IN THE BRAIN TISSUE AND THE BLOOD FOLLOWING BRAIN INJURY
Xu Ruxiang. Department of Neurosurgery, Zhujiang Hospital, First Military Medical University, GuangzhouYi Shengyu. Deparlment of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi' an
The changes in calcium, calmodulin (CaM) and water contents of brain tissues were studied in the rat after brain injury, which was induced by a falling weight. The effect of anisoda-mine (654-2) on changes in calcium, CaM contents and brain edema were investigated. The results showed that: (0 contents of calcium in the brain cortex and serum were increased after brain trauma, and alteration in calcium in the brain cortex was more prominent than that of serum. It reached 24.12±10.22 mmol/kg dry brain 48h after injury, which was two times of control values at that time; (2) the augmentation of CaM in the brain cortex and plasma was remarkable. It reached its peaks at 48h, and its values were 2.6 to 2.8 times of control values respectively; (3) the increment of water content in the white matter was remarkable, which was closely correlated to the changes of calcium and CaM; (4) the injured animals that received anisodamine showed reduction in the levels of calcium and CaM distinctively, and the degree of brain edema was less.