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《Medical Journal of Chinese People's Liberation Army》 2002-10
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STUDY ON APOPTOSIS INDUCED BY ELECTROMAGNETIC PULSE IN NEURONS OF CEREBELLAR GRANULAR LAYER

Zhao Meilan, Wang Dewen, Cao Xiaozhe. Institute of Radiation Medicine, Academg of Military Medical Sciences, Beijing 100850  
By observing apoptosis and morphological changes in primary culture of neurons from cerebellar granular layer, the neurons were irradiated with EMP (electromagnetic pulses), the possible injury mechanism was explored. The changes in death and apoptosis of the neurons were detected by MTT and flow cytometry, respectively. The slides stained with HE and TUNNEL were examined with light and fluorescence microscopy. The results showed that not only death of the neurons occurred immediately, but also apoptosis appeared after irradiation with EMP. Our conclusion is EMP can promote necrosis and apoptosis of neurons from cerebellar granular layer at early stage, which may result from DNA injury induced by EMP.
【Fund】: 全军医学科研“十五”计划指令性项目资助课题(编号01L023)
【CateGory Index】: Q64
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