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《Medical Journal of Chinese People's Liberation Army》 2004-08
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Study on the mechanism of therapeutic effect of "Yichantang" in the treatment of Parkinson disease

Dou Yongqi,Yang Minghui,Liu Yi et al . General Hospital of PLA,Beijing 100853,China  
Objective To explore the mechanism of therapeutic effect of Yichantang in the treatment of Parkinson′s disease (PD). Methods A rat model of PD was replicated. The experimental animals were divided into a normal control group,a normal saline control group and a Yichantang group. Changes in the rats' behavior pattern was obrerved. Using the technique of intracerebral dialysis,the content of catecholamine like substances in the nigral extracellular fluid(NECF)was measured by means of high performance liquid chromatography(HPLC). Changes in the affinity and quantity of M and DA receptors were determined too. Results Yichantang markedly improved the rats' rotation behavior,and enhanced the Bmax and KD of DA and M receptors in the brain tissues on the side of lesion. The levels of DOPAC,HVA,DA and 5-HT in the NECF of the side of lesion in the Yichantang group were significantly higher than that of the normal saline group ( P 0.05). Besides,the number of substance nigra cells was significantly larger in Yichantang group than that in the normal saline group,and the volume and structure of the neurons,intracellular Golgi complex and mitochondria were similar to the normal. Conclusion Yichantang can facilitate the repair of the injured substantia nigra neurons,increase the secretion of DA from striatum-substantia nigra system, and increase the affinity and sensitivity of DA and M receptors by stimulating the receptor system of the PD rats. All these effects may contribute to the therapeutic effect of Yichantang.
【Fund】: 军队“十五”医药卫生科研基金 (编号 0 1MA1 1 6)资助课题
【CateGory Index】: R742.5
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