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《Medical Journal of Chinese People's Liberation Army》 2005-06
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A comparison between two therapeutical strategies of hepatocarcinoma correlated to HCC cell hematogenous dissemination

Ma Huanxian, Gu Wanqing, Li Chonghui et al . Department of Hepatobiliary Surgery, General Hospital of PLA, Beijing 100853, China  
Objective To compare and assess the effect of surgical resection(SR) and microwave coagulation therapy(MCT) on the treatments of hepatocellular carcinoma(HCC) correlated to HCC cell hematogenous dissemination. Methods Nested RT PCR was employed on 92 HCC patients (TNM pStage Ⅱ) and 10 benign hepatopathies, for whom all the AFP mRNA, MAGE 1 mRNA and MAGE 3 mRNA were negative, to detect the changes of above targets in peripheral blood before and after SR and MCT. Results For the HCC patients (TNM pStage Ⅱ, tumor diameter ≤3cm), after MCT the AFP mRNA expressed in only one case, MAGE 1 mRNA and MAGE 3 mRNA were not expressed in any of them, the total positive rate was 4 3%(1/23), while after SR the total positive rate (at least one gene was detected) was 30 43%(7/23), significantly higher than that of MCT group ( P 0 05). For those patients whose tumor diameter 3cm the total positive expression of AFP mRNA, MAGE 1 mRNA and MAGE 3 mRNA was 21 7%(5/23) after MCT and 34 8%(8/23) after SR. Conclusion Both the therapy (SR and MCT) may cause the iatrogenic HCC cell hematogenous dissemination. When the tumor diameter ≤3cm the dissemination probability in the patients with TNM pStage Ⅱ was lower by MCT than by SR, but no significant difference existed between the both therapy when the tumor diameter 3cm.
【CateGory Index】: R735.7
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