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《Medical Journal of Chinese People's Liberation Army》 2005-10
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Antagonistic effect of sodium butyrate against high mobility group box 1 protein in rats with sepsis

Zhang Litian, Yao Yongming, Lu Jiaqi et al. Burns Institute, 304 Div ision, General Hospital of PLA(Formerly 304 Hospital of PLA), Beijing 100037, Ch ina  
Objective To investigate the effects and significan ce of administration of sodium butyrate, a short chain fatty acid, on inhibiting t he expression of high mobility group box 1 protein (HMGB1) in rats with impendin g sepsis. Methods Sepsis rat model was reproduced by cecal liga tion puncture (CLP). 60 male Wistar rats were randomly divided into four groups as follows: normal control group (n=10), sham operation group (n=10), CL P group (n=20, further divided into 12h and 24h post-CLP subgroups, 10 rats for each subgroup), and sodium butyrate treatment group (n=20, further divi ded into 12h and 24h post-CLP subgroups, 10 rats for each subgroup). At the two time points animals in all groups were sacrificed, and meanwhile, blood and tis sue samples from liver, lungs, kidneys and small intestine were harvested to det ermine parameters of the organ functions, and RT-PCR taking GAPDH as the intern al standard was used to detect the expression of HMGB1 mRNA. Additional experime nt was performed to observe the treatment effects of sodium butyrate on septic r ats (n=57). Results After the cecal ligation puncture, HMGB 1 mRNA levels significantly increased in the liver, lungs, kidneys and intestine , while the increases were effectively suppressed by the use of sodium butyrate (P0.05-0.01). Earlier treatment using sodium butyrate may markedly reduc e both the serum alanine transaminase (ALT) and creatinine (Cr) levels at 12h, a nd the activity of pulmonary myeloperoxidase (MPO) was also suppressed at 24h po st-CLP. Furthermore, treatment with sodium butyrate could significantly improve the 1~6 days′ survival in animals subjected to CLP (P0.05-0.01). Conclusions Sodium butyrate might have therapeutic potential for syst emic inflammation mediated by HMGB1.
【Fund】: 国家重点基础研究发展规划项目(编号G1999054203、2005CB522602);; 国家杰出青年基金课题(编号30125020);; 军队十五医药卫生科研课题(编号01MA207)
【CateGory Index】: R631
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