Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Medical Journal of Chinese People's Liberation Army》 2011-02
Add to Favorite Get Latest Update

Expression and significance of C-fos and proliferating cell nuclear antigen in the small intestinal tissue of human fetus

LIU Xue-hong,ZHANG Yong.Department of Histology and Embryology,School of Medicine,Shaoxing University,Shaoxing,Zhejiang 312000,China  
Objective To explore the expression rule of proliferating cell nuclear antigen(PCNA),C-fos proteins and apoptosis genes in the small intestinal tissue of human fetus.Methods At the second-to fourth-month of gestation,the expressions of cell proliferation and apoptosis were observed in 16 specimens of human fetal small intestinal tissue by using the immunohistochemical methods and terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling(TUNEL).Results At the second to fourth month of gestation,all the PCNA and C-fos proteins were positively expressed in the small intestinal tissues and cells of human fetus.With the increase in gestational period,the positive cell number and average intensity(AI) of PCNA protein increased gradually(P0.01).The positive cell number of C-fos protein increased first,and then decreased,while the AI of C-fos protein stably increased in the small intestinal tissues and cells of human fetus(P0.01).At the second to fourth month of gestation,TUNEL positive cells were seen to distribute in each layer of the small intestinal tissues of human fetus.With the increase of age,all the positive cell number and AI of TUNEL positive cells showed a tendency of decrease following increase in the small intestine of human fetus(P0.01).Conclusions PCNA,C-fos and apoptosis gene participate in adjusting the growth and development of the cells and tissues in the small intestine of human fetus.In the third month of gestation,especially,proliferation and apoptosis are significantly increased in the small intestinal tissue of human fetus,which may be the key period of intestinal tissue development.
【Fund】: 浙江省教育厅科研计划项目(Y200805569);; 绍兴文理学院重点资助项目(08LG1018)
【CateGory Index】: R329.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved