FFECT OF ANISODAMINE ON THE CONTENT OF PRINCIPAL,FATTY ACIDS INTHE MEMBRANE LIPIDS OF ISCHEMIA REPERFUSED MYOCARDIAL INJURIES
Xu Zichao,Li Xiaohua , Yao Xiujuan , et al. Fourth Military Medical University. Xi' an , 710032
In the present experiment, anesthesized rats were subjected to 15min of myocardial is- chemia induced by coronary ligation and followed by 10 min of reperfusion. Moreover, 1 min prior to reperfusion,3.0 and 5.0mg/kg anisodamine,1.0 ml/kg normal saline and 75 U/kg superoxide dismutase were intravenously administered, respectively, Then the animals were sacrificed for isolation of hearts and the content of principal fatty acids in the membrane lipids of reperfused myocardium waxdetermined by gas chromatography. The findings showed that there was a marked decline in the level of princlpal unsatu- rated fatty acids (P0. 01) and anisodamine could terminate the decrease(P0. 01). It was also found that superoxide dismutase exerted similar effect to anisodamine.