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《MEDICAL JOURNAL OF CHINESE PEOPLE'S LIBERATION ARMY》 1997-01
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AN EXPERIMENTAL STUDY OF PULMONARY SURFACTANT CHANGES AFTER LUNG INJURY INDUCED BY ENDOTOXIN IN RATS

Wang Shengxian,Yu Zhonghe,Chen Yisheng et al. Chengdu General Hospital of Chengdu Command,Chengdu 610083  
The ultrastructural changes of lung,pulmonary homogenates sufactant (ST) and the area density of alveolar septa were investigated at 1,5,12,24,48 and 72h after lipopolysaccharide (LPS) injection.The most prominent changes were pulmonary tissue congestion,edema,collapse,type Ⅱ epithelial cells (PⅡ) swelling and degeneration.ST content and it's activity decieased while the area density of alveolar sepat increased.They had a significanly negtive correlation ( r =-0 9395, P 0 01).The above changes were more severe 1 to 48h after LPS injection.The results indicated that LPS may cause direct or indirect damage to the PⅡ and ST system and that it accelerate the development of pulmonary edema,collapse and respiratary distress syndrome.
【Key Words】: lung injury surfactant type Ⅱ epithelial cells endotoxin
【CateGory Index】: R361.3
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