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《Acta Laser Biology Sinica》 2014-01
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Thiostrepton induces autophagic cell death in non-small-cell lung cancer cells

ZOU Zhengzhi;NIE Peipei;NI Yirong;ZHOU Xiaoming;MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science,College of Biophotonics,South China Normal University;Guangzhou kingmed Diagnostics Corporation;  
Autophagy is a fundamental cellular process that controls cells in a normal homeostatic state by recycling nutrients to maintain cellular energy levels for cell survival through the turnover of proteins and damaged organelles. Whereas,persistent activation of autophagy can cause excessive depletion of cellular organelles and essential proteins,leading to caspase-independent autophagic cell death. Therefore,inducing cell death via this autophagic pathway might be an alternative approach for cancer therapy. Here,we show that the thiazole antibiotic thiostrepton decreased cell viability and induced cell apoptosis in non-small-cell lung cancer( NSCLC) PC-9 cells. Additionally,we found thiostrepton induced cell autophagy in PC-9 cells. Moreover,the cell apoptosis induced by thiostrepton could be blocked by 3-Methyladenine( 3-MA),a autophagy inhibitor. These findings suggested that thiostrepton can promote the autophagic death of human NSCLC cells. Moreover,this study provided evidence that administration of thiostrepton combined with autophagy inducer may be an effective therapeutic strategy for targeting human non-small-cell lung cancers.
【Fund】: 科技部国家重点基础研究973计划项目(2011CB910402;2010CB732602);; 教育部“长江学者与创新团队计划”创新团队项目(IRT0829);; 国家自然科学基金项目(81101741);; 华南师范大学青年教师培育基金(13KJ19)资助
【CateGory Index】: R734.2
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