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《Acta Laser Biology Sinica》 2017-02
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Becn1 Regulates Cell Apoptosis of Lung Cancer by Mitochondrial Apoptosis Pathway

WANG Yuanhang;XIA Shengyuan;ZHANG Lan;GMU-GIBH Joint School of Life Sciences,Guangzhou Medical University;  
Autophagy related gene Becn1 is low expression in many tumors,such as lung cancer,which can inhibit the occurrence and development of tumors. At present,it's reported that Becn1 can regulate the occurrence and development of lung cancer by autophagic pathway and autophagy is closely related to apoptosis,but the mechanism has not been fully elucidated. In this study,PC9 and A549 lung cancer cell lines were selected and established the models with high Becn1 expression. The co-immunoprecipitation and GFP-BECLIN1 and DsRed-Mit fluorescence co-localization experiments were used to confirm that Becn1 could regulate cell apoptosis in lung cancer through mitochondrial pathway.
【Fund】: 国家自然科学基金项目(81102159);; 广东省自然科学基金项目(2016A030313567);; 广州市教育局广州市属高校“羊城学者”科研项目(12A010D);; 广州市科技计划项目(201607010035)
【CateGory Index】: R734.2
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【Citations】
Chinese Journal Full-text Database 2 Hits
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【Co-citations】
Chinese Journal Full-text Database 6 Hits
1 SHAN Yuqiang;WU Yi;YU Panpan;ZHU Akao;KONG Wencheng;ZHENG Sixin;JIN Huicheng;Hangzhou First People's Hospital;Hangzhou Hospital Affiliated to Nanjing Medical University;;Relationship between Susceptibility of Gastric Cancer and Gene Polymorphism of IL-17A[J];激光生物学报;2017-04
2 WANG Yuanhang;XIA Shengyuan;ZHANG Lan;GMU-GIBH Joint School of Life Sciences,Guangzhou Medical University;;Becn1 Regulates Cell Apoptosis of Lung Cancer by Mitochondrial Apoptosis Pathway[J];激光生物学报;2017-02
3 ZHANG Lili;GENG Huixia;SHI Zhenyu;DENG Jinbo;WANG Lai;Henan University,Nursing School;Henan University,College of Life Science;;Effect of Different Fixatives and Passage Number on Fluorescence Intensity of pDsRed2-Mito Plasmid[J];河南大学学报(自然科学版);2016-06
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