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《Journal of Yangtze University(Natural Science Edition)》 2009-03
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Inhibitive Effect and Mechanism of Icariin on Adhesion and Migration of AGS Cells

YAN Jin (Medical School of Yangtze University,Jingzhou 434023,China)  
Objecctive:To explore the inhibitive effect and mechanism of Icariin on adhesion and migration of AGS cell.Methods:Adhesive ratio was detected by adhesion assay,migration rate was measured by wound healing assay.Results:After AGS cells were treated with Icariin of 2,4,8,12,16μg/ml for 24h,adhesive ratios were 73.65%,46.24%,43.28%,41.59%,20.36% respectively.Compared with the 2μg/ml and 16μg/ml groups,the adhesive ratio of 4μg/ml group was significantly different(P0.01),but with the 8μg/ml group and 12μg/ml group,the value of 4μg/ml group had no significant difference(P0.05).After AGS cells were treated with 4μg/ml Icariin for 24h,the migration rate was markedly reduced(P 0.01).Conclusion:Icariin can inhibit adhesion and migration of AGS cells so that it may play an anti-metastatic role.
【Key Words】: Icariin AGS cell Cell migration
【CateGory Index】: R735.2
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【Citations】
Chinese Journal Full-text Database 4 Hits
1 WANG Da-guang; ZHU Wen-yuan; MA Hui-jun(Department of Dermatology; the First Affiliated Hospital; Nanjing Medical University; Nanjing 210029; China );Effects of 6 kinds of monomers extracted from Chinese medicines including icariine onmelanogenesis in Cloudman S91 melanoma cells[J];Journal of Clinical Dermatology;2004-04
2 ZHANG Zhi-hong~1,SHU Hong~2,LIN Ming-bao~3(1.The Fuzhou Medical Branch College of Nanchang University,Fuzhou 344000,China;2.The First Affiliated Hospital of Nanchang University,Nanchang 330006,China;3.Jiangxi Province Academy of Chinese Medicine and Pharmacology,Nanchang 330077,China);Experimental Study on Icariin Induced Apoptosis of Cultured Liver Cancer Cell SMMC-7721[J];Practical Clinical Medicine;2006-11
3 LIANG Guang-bo 1, ZHANG Guo-ping 1, JIN Hui-ming 1, TANG Da-kan 2 ( 1Department of Physiology and Pathophysiology,? 2?Department of Medical Bioengineering,Shanghai Medical College,Fudan University,Shanghai 200032,China);Establishment of quantitative measurement method of cell migration in vitro and it's application[J];Chinese Journal of Pathophysiology;2004-02
4 CUI Xin-ying,CUI Xin-yu,ZHANG Cheng-yi(Pharmacy College of Beihua University,Jilin 132013,China);Experimental Study of Effect of Longspur epimedium Glycoside on Increasing Immunity Function[J];Journal of Beihua University(Natural Science);2008-03
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 CUI Ying1,BAI Liu2,ZHANG Jin-chao2,YANG Fu-chun2,LI Sheng3,ZHAO Ying1,GAO Ying1,2(1.Key Laboratory of Medical Cellular and Molecular Biology,Dalian Medical University,Dalian 116044,China;2.Department of Biochemistry and Molecular Biology,Dalian Medical University,Dalian 116044,China;3.Department of Neurology,the First Affiliated Hospital of Dalian Medical University,Dalian 116011,China);Establishment of assay for smooth muscle cell migration induced by PDGF in rat aorta[J];Journal of Dalian Medical University;2009-03
2 WEN Xianmei 1, WEI Lei 1, ZHANG Jingwei 2, PENG Xiaochun 1, WANG Tingting 1, ZHANG Lijun 1, LI Hua 1 1Dept. of Pathophysiology, Schoolo of Medicine, Wuhan University, Wuhan 430071,China 2Dept. of Oncology, Zhongnan Hospital of Wuhan University, Wuhan 430071,China;Inhibitive Effect and Mechanism of Matrine on Adhesion and Migration of HeLa Cells[J];Medical Journal of Wuhan University;2006-02
3 PENG Xiaochun~(1,2),ZHANG Jingwei~(3),WEI Lei~(1),WEN Xianmei~(1),WANG Tingting~(1),ZHANG Lijun~(1),LI Hua~(1)~1Dept.of Pathophysiology,School of Medicine,Wuhan University,Wuhan 430071,China~2Dept.of Pathophysiology,Medical School of Yangtze University,Jingzhou 434000,China~3Dept.of Tumor Surgery,Zhongnan Hospital of Wuhan University,Wuhan 430071,China;Inhibitive Effect of Matrine on Adhesion and Migration of SGC7901 Cells[J];Medical Journal of Wuhan University;2007-01
4 Chen Longju1,Jiang Fei3,Lu Jinchang3,Qi Shaohua2,Wang Peijun1,Wang Hanqin1,2(1.Department of Anatomy,2.Institute of Life Scince,Affiliated Taihe Hospital,3.Department of Respiration,Affiliated Taihe Hospital,Yunyang Medical College,ShiYan 442000,China);Effects of PI3K inhibitor on bFGF-induced proliferation and migration of vascular smooth muscle cells[J];Chinese Journal of Anatomy;2009-03
5 WANG Da-guang,ZHU Wen-yuan,MA Hui-jun,LI Cheng-rang,YUE Xue-zhuang(Department of Dermatology,the First Affiliated Hospital,Nanjing Medical University,Nanjing210029,China);Inhibitory effects of icariin on melanogenesis of human epidermal melanocytes[J];Journal of Clinical Dermatology;2004-08
6 WANG Da-guang,ZHU Wen-yuan,MA Hui-jun,YUE Xue-zhuang,LI Cheng-rang(Department of Dermatology and Venereology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China);Betamethasone actives cultured amelanotic melanocytes derived from outer root sheath of human hair follicle[J];Journal of Clinical Dermatology;2008-12
7 CAO Xiao-gang,YU Gang,WANG Li-jun(Institute of Medicine Resource,College of Pharmacy,Southwest University,Chongqing 400715,China);Progress on Salidroside[J];Food and Drug;2007-07
8 WANG Ming-jie, CAI Wen-jie, CAO Yin-xiang, YU Zhang△, ZHU Yi-chun (Department of Physiology and Pathophysiology, △ Department of Electroscopy, Shanghai Medical College, Fudan University, Shanghai 200032,China);Observation of the Stimulative Effect of Basic Fibroblast Growth Factor on ECV304 Cell Migration with Electron Microscope[J];Journal of Shanghai Medica(University);2005-06
9 LIANG Guang-Bo, ZHANG Guo-Ping, JIN Hui-Ming , QIAN Rui-Zhe Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai 200032, China;Dynamic changes in focal adhesion kinase during cell migration induced by bFGF and the significance[J];Acta Physiological Sinica;2004-04
10 Chen Longju Zhang Fugui Tang Jie et al Department of Anatomy,Yunyang Medical College(Shiyan 442000);Effects of PD and SB on EGF-induced proliferation and migration in vascular smooth muscle cells[J];Shaanxi Medical Journal;2009-09
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 ZHU Jin-quan, ZHANG Kun-he, HUANG De-qiang,YU Gong-qing, XIE Yong, WANG Chong-wen (Institute of Digestive Diseases, Jiangxi Medical College, Nanchang 330006,China; Laboratory of Electron microscopy,Jiangxi institute of Medical Sciences,Nanchang 330006,Chi;A Preliminary Investigation about the Morbidity and Mortality of Common Cancers in Digestive System in Poyang Lake Epidemic Region with Schistosome[J];Acta Academiae Medicinae Jiangxi;2001-01
2 Lei Tiechi, Zhu Wenyuan, Xia Minyu, Zhang Meihua, Fan Weixin(Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, 210029);Comparative studies on regulation of melanogenesis in the responese of murine melanoma cells to ammonium glycyrrhizinate, arbutin and hydroquinone[J];JOURNAL OF CLINICAL DERMATOLOGY;2000-02
3 LIU Dong,ZHU Wen-yuan,TAN Cheng(Department of Dermatology,The First Affiliated Hospital,Nanjing Medical University,Nanjing210029,China);Effects of glucocorticoids on melanogenesis in Cloudman S91 melanoma cells[J];Journal of Clinical Dermatology;2003-01
4 Yang Jingyu,Yu Qinghai,Li Shuang,Xu Jinghua,Ma Junfeng;Immunopotentiation of Total Flavones of Epimedium on Immunodepressant Mice[J];JOURNAL OF SHENYANG PHARMACEUTICAL UNIVERSITY;1998-02
5 QIN Ying 1, YANG Jun 2, ZHU Ling-qun 1, NIU Fu-ling 1, CUI Wei 1, WANG Shuo-ren 1, JIANG Liang-duo 1 ( 1 The Key Internal Medicine Laboratory, Beijing University of Traditional Chinese Medicine, Beijing 100700, China; 2 Department of kidney, Navy General Hospital of PLA, Beijing 100037, China);Proliferation and apoptosis of human umbilical vein endothelial cells induced by oxidized low density lipoprotein[J];Chinese Journal of Pathophysiology;2003-03
6 Lei Tiechi, Zhu Wenyuan, Xia Mingyu, et al. (the First Hospital Affiliated to Nanjing University of Medical Sciences, Nanjing 210029);Studies on the Effect of TCM on Melanin Biosynthesis I. Inhibitory Actions of Ethanolic Extracts of 82 Different Chinese Crude Drugs on Tyrosinase Activity[J];CHINESE TRADITIONAL AND HERBAL DRUGS;1999-05
7 Wang Jianhua (Wang JH),Lei Fan (Lei F),Cui Jingrong (Cui JR)(School of Pharmacy,Beijing Medical University,Beijing 100083);Inhibitory effect of 20 Chinese crude drugs on tyrosinase[J];CHINESE PHARMACEUTICAL JOURNAL;2000-04
8 LiQingnan(LiQN),LiaoJinmin(LiaoJM),WuTie(WuT),etal(BoneBiologyLaboratory,GuangdongMedicalColege,Zhanjiang524023);EpimediumsagitatumMaximpreventinghormone┐inducedosteoporosisinrats[J];CHINESE PHARMACEUTICAL JOURNAL;1996-08
9 Zeng Nan, Meng Xianli, Zhang Yi, Lai Xianrong, Zheng Jun, Cheng Longqiong and Ren Changmao (Chengdu University of TCM 610075);Studies on the Antioxidative Effect of Constituents of Herba Epimedii (ESPS)[J];CHINA JOURNAL OF CHINESE MATERIA MEDICA;1997-01
10 SUN Huiqin, BIAN Xiuwu *, CHEN Yisheng, SHI Jingquan. *Department of Pathology, Third Military Medical University, Chongqing 400038, China;The effect of nordihydroguaiaretic acid on endothelial cell migration induced by glioma cells[J];CHINESE JOURNAL OF PATHOLOGY;2000-01
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