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《Chinese Journal of Family Planning》 2014-12
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A meta-analysis of ureaplasma urealyticum and chlamydia trachomatis infections with female infertility

DING Nan;WANG Fang;JIAN Qiliang;WANG Peili;Reproductive Medicine Center of the Second Hospital of Lanzhou University;Kangtai Hospital of Gansu Province;  
Objective:To systematically evaluate associations between ureaplasma urealyticum(Uu)infection and chlamydia trachomatis(Ct)infection with female infertility.Methods:According to the strict inclusive and exclusive criteria,CNKI,CBMdisc,Wanfang,VIP and PubMed databases were searched.Furthermore,we manually searched the relevant references published from 2000 to 2014.Two reviewers selected trials and assessed trial quality independently by using the Cochrane Handbook 5.3.A meta-analysis was performed with the fix-effects model or randomeffects model according to the heterogeneity.Results:A total of 181 relevant studies,involving 132 Chinese studies and 49 foreign studies were retrieved.Eventually,13 eligible Chinese studies involving 3760 patients were included.The results of the meta-analysis were as follows:The merged odd ratio(OR)of Uu,Ct and(Uu + Ct)were 6.41(95%CI:4.85-8.47),6.76(95%CI:5.33-8.58)and 10.74(95%CI:6.87-16.81),respectively.The incidences of infertility in all groups were different when compared with the corresponding control groups.Conclusion:There are significant associations between Uu and Ct infections with female infertility,suggesting that we should pay enough attention to the detection in infertile women with Uu and Ct infections.
【Fund】: 国家自然科学基金(81202959);; 中央高校重点培育项目(lzujbky-2013-m04)
【CateGory Index】: R711.6
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