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Research of Basil capsule on expression of HIF-1α,VEGF in hypoxia environmental and sICAM-1 in blood serum after TACE of rat hepatoma

SHI Chuanwen,LIU Fuli,LIANG Xiaodong,et al.Taishan Sanitarium of Shandong Province,Taian,271000,China.  
Objective:To observe the influence of Basil capsule on expression of HIF-1α,VEGF and sICAM-1 in blood serum.In hypoxia environmental after TACE of rat hepatoma.Methods:Animals were randomly divided into five groups after models were built:non-TACE group,TACE+NS group,TACE+mini-dose Basil capsule group,TACE+ middle-dose Basil capsule group,TACE+ large dose Basil capsule group.For non-TACE group rats were only for abdominal operations,without TACE technique.The remaining four groups of rats were carried out TACE technique.Carried out different doses of Basil capsule gavage treatment after TACE.Ten days later,sacrifice the rats.Detected the expression of HIF-1α,VEGF in hepatoma focus with immunohistochemistry method.Detected the level of sICAM-1 with ELISA.Results:Compared with the group of Non-TACE,TACE +NS group had a higher expression of VEGF,HIF-1α,and SICAM-1 in blood serum(P0.05).Different dose Basil capsules had a lower expression than TACE+NS group (P0.05).Conclusion:Basil capsule can obviously improve hypoxia environmental of rat hepatoma after TACE and down regulation the expression of VEGF,HIF-1α,and SICAM-1 in blood serum.Basil capsule has dose dependent inhibitory action on invasion and metastasis of rat hepatoma after TACE.
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