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Effects of nitric oxide inhibition on inflammatory response in acute lung injury

Qiu Haibo,Chen Dechang,Pan Jiaqi,et al.Department of Critical Care Medicine,Nanjing Railway Medical College Hospital, Nanjing 210009  
Aim:To observe the effects of nitric oxide inhibition on inflammatory reaction by lipopolysaccharides(LPS) induced lung injury.Methods:The levels of tumor necrosis factor α(TNFα),interleukin 1β(IL 1β),IL 6,and IL 10 in mouse bronchoalveolar lavage fluid(BALF)and plasma were measured by ELISA.Nitrite was measured by Griess reaction.In animal model,the degree of LPS induced acute lung injury was evaluated by the wet and dryweight ratio of lung.Results:The levels of TNFα,IL 1β,IL 6,IL 10 and nitrite in mice plasma and BALF after LPS 20 mg/kg ip increased markedly at 12 h.Dexamethasone(Dex)70mg/kg injected ip at 30 min before ip LPS decreased the concentrations of TNFα,IL 1β,IL 6,IL 10,and nitrite in plasma.But IL 1β,IL 6,and IL 10 decreased in BALF.S methylisothiourea sulfate(SMT),a nitric oxide synthetase inhibitor,85mg/kg injected ip at 30 min before LPS increased the levels of IL 1β,and IL 6 in plasma.In BALE,TNFα increased,whereas IL 1β,IL 6,and IL 10 remained unchanged.Compared to LPS group,the wet and dry lung weight ratio decreased significantly in Dex group,but the ratio increased in SMT group.Conclusion:Inhibition of nitric oxide may result an enhanced production of proinflammatory cytokines and an increased LPS induced lung injury.
【CateGory Index】: R563.1
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