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《JOURNAL OF EMERGENOY MEDICINE》 1999-03
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Effects of nitric oxide inhibition on inflammatory response in acute lung injury

Qiu Haibo,Chen Dechang,Pan Jiaqi,et al.Department of Critical Care Medicine,Nanjing Railway Medical College Hospital, Nanjing 210009  
Aim:To observe the effects of nitric oxide inhibition on inflammatory reaction by lipopolysaccharides(LPS) induced lung injury.Methods:The levels of tumor necrosis factor α(TNFα),interleukin 1β(IL 1β),IL 6,and IL 10 in mouse bronchoalveolar lavage fluid(BALF)and plasma were measured by ELISA.Nitrite was measured by Griess reaction.In animal model,the degree of LPS induced acute lung injury was evaluated by the wet and dryweight ratio of lung.Results:The levels of TNFα,IL 1β,IL 6,IL 10 and nitrite in mice plasma and BALF after LPS 20 mg/kg ip increased markedly at 12 h.Dexamethasone(Dex)70mg/kg injected ip at 30 min before ip LPS decreased the concentrations of TNFα,IL 1β,IL 6,IL 10,and nitrite in plasma.But IL 1β,IL 6,and IL 10 decreased in BALF.S methylisothiourea sulfate(SMT),a nitric oxide synthetase inhibitor,85mg/kg injected ip at 30 min before LPS increased the levels of IL 1β,and IL 6 in plasma.In BALE,TNFα increased,whereas IL 1β,IL 6,and IL 10 remained unchanged.Compared to LPS group,the wet and dry lung weight ratio decreased significantly in Dex group,but the ratio increased in SMT group.Conclusion:Inhibition of nitric oxide may result an enhanced production of proinflammatory cytokines and an increased LPS induced lung injury.
【CateGory Index】: R563.1
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【References】
Chinese Journal Full-text Database 9 Hits
1 QIN Kai-xiu,JIAN Hua-gang(Department of Emergency,Second Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400010,China);Expression of inflammatory media in acute lung injury induced by endotoxin in mice[J];Chongqing Medicine;2007-04
2 Li Suzhi,Zheng Bihai,Wang Hongbing,Gao Yanming,Zhu Lungui 1,Wang Lei 1,Cai Zhixing High Altitude Medical Research Center of PLA 1Health Team of 77606 Troops in Tibet Military Area;The Assessment of Effect of Gaoyuankang Capsules on Serum Level of NO and IL-1、IL-6、IL-8 in Acute Exposed Plateau People[J];Journal of High Altitude Medicine;2005-01
3 QIU Haibo,YANG Yi,ZHOU Shaoxia,et al.Department of Critical Care Medicine,Zhongda Hospital and School of Clinical Medicine,Southeast University,Nanjing 210009,China;The role of nuclear factor kappa B activation in rats with acute lung injury[J];Journal of Emergenoy Medicine;2003-01
4 YANG Yi,QIU Haibo,ZHOU Shaoxia,et al. Department of Critical Care Medicine,Zhongda Hospital and School of Clinical Medicine,Southeast University,Nanjing 210009,China;Effect of S-methylisothiourea sulfate on pulmonary nuclear factor-κΒ in mice with acute lung injury[J];Jiangsu Medical Journal;2004-02
5 QIU Haibo,YANG Yi,ZHOU Shaoxia,et al. Department of Critical Care Medicine,Zhongda Hospital and School of Clinical Medicine,Southeast University,Nanjing 210009,China;Effect of different concentration of nitric oxide on pulmonary inflammatory response in mice with acute lung injury[J];Jiangsu Medical Journal;2004-12
6 Yu Zhui 1, Xu Xiyong 1, Li Yinping 2, et al 1 Emergency Department of Zhongnan Hospital, Wuhan University,Wuhan 430071, China 2 Pathophysiology Department of Medical School, Wuhan University, Wuhan 430071, China;The Influence of Dexamethasone on the Acutely Injured Lung and the Potential Mechanisms[J];Journal of New Medicine;2004-04
7 Qin Kaixiu,Jian Huagang(Department of Emergency,the Second Affiliated Hospital of Chongqing University of Medical Sciences,Chongqing,China 400010);Protective Effection of Ulinastatin on Acute Lung Injury Induced by Endotoxin in Mice[J];China Pharmaceuticals;2006-18
8 WANG Yi-zhong~(2),CUI Xiao-lan,GAO Ying-jie~(1),GUO Shan-shan~(1),WANG Xiu-kun~(1),HUANG Yang~(1),ZHAO Ye~(1),GONG Weng-feng~(1)(1.Institute of Chinese Meteria Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;2.Aerospace Center Hospital,Beijing 100049,China);Antivirus effects of extract from gardenia[J];China Journal of Chinese Materia Medica;2006-14
9 YANG Yi,QIU Haibo,ZHOU Shaoxia,XU Hongyang,LIU Shaohua,ZHENG Ruiqiang,HUANG Yingzi. Department of Critical Care Medicine,Zhongda Hospital and School of Clinical Medicine,Southeast University, Nanjing 210009,Jiangsu China;Effect of inhaled nitric oxide on pulmonary inflammatory response in mice with acute lung injury[J];Chinese Critical Care Medicine;2002-12
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Xiuqin, XIE Yanying, WANG Peng, et al Department of Pharmacology, Institute of Meteria Medica, Shandong Academy of Medical Science, Ji′nan 250062;;THE THERAPEUTIC EFFECTS OF FEI-TONG-KOU-FU-YE ON BLEOMYCIN INDUCED PULMONARY FIBROSIS IN RATS[J];Acta Acadimae Medicinae Qingdao;2003-01
2 Jian Hua FU, Xin Dong XUE. Department of Pediatrics, Second Affiliated Hospital, China Medical University, Shenyang 110004, China;Changes of ultrastructure and oxidative stress reaction of lungs in premature rats with chronic lung disease induced by hyperoxia[J];The Chinese Journal of Contemporary Pediatrics;2004-01
3 TAN Zhao-hua,XU Jun-mei, YANG Zhao-yun,et al. Department of Anesthesiology, The Second Xiangya Hospital, Central South University,changsha 410011,China;The Effects of Ulinastatin on Proinflammatory Cytokine and Oxygen Free Radicals During Acute Lung Injury in Rabbits[J];Journal of Chinese Physician;2004-10
4 Yang Zili; Wang Zhengguo; Zhu Peifang (Research Institute of Field Surgery, Daping Hospital, Third Military Medical University, Chongqing,400042 );The changes of NO and its synthase in the lungs during acute lung injury in rats[J];ACTA ACADEMIAE MEDICINE MILITARIS TERTIAE;1998-04
5 LI Xue jun, CUI She huai (Department of Respiratory Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Effects of Panax notoginseng saponin on macrophage inflammatory protein-1α and monocyte chemoattractant protein-1 in plasma in rats with pulmonary fibrosis[J];Acta Academiae Medicinae Militaris Tertiae;2003-06
6 Mou Xinbing,et al The General Hospital of Tibet Military Command;THE CHARACTERISTICS OF INFLAMMATION IN PATIENTS WITH HAPE[J];Journal of High Altitude Medicine;2002-04
7 Zheng Bihai, Li Suzhi,Wang Hongbin, Gao Yanming, Yao Wenxing High Altitude Medical Research center of PLA, Lasa;THE EFFECT AND SIGNIFICANCE OF NO ON SERUM INTERLEUK-8 IN PATIENTS WITH ACUTE HIGH ALTITUDE DISEASE[J];Journal of High Altitude Medicine;2003-04
8 Liu Wei min,Xu Qi yong,Lin Yu hui,et al Department of Respirology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China;Study of Influence of 25% Angelica Injection to Bleomycin-induced Pulmonary Fibrosis[J];Journal of Hubei Medical University;2001-04
9 Yu Zhui, Xu Youzhi, Zhou Xiaoyang, et al Department of Emergency, Zhongnan Hospital,Wuhan University,Wuhan 430071, China;Chronological Changes of iNOS mRNA and eNOS mRNA Expression in Rats' Acutely Injured Lungs[J];Journal of Hubei Medical University;2003-01
10 WANG Rui-ke,ZHAO Shuang-ping,YANG Xin-ping,CAI Hong-wei * (Department of Anesthesiology, Xiangya Hospital,Central South University, Changsha 410008, China);Effect of ulinastatin on lung injury after dilute hydrochloric acid aspiration[J];;2004-03
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 GUO Jian, SONG Da-lin, WANG Yan-ming (Laboratory of Endocrinology, Qingdao Hiser Medical Group, Qingdao 266033, China);;ESTABLISHMENT OF MODEL IN DIABETES MELLITUS COMPLICATED WITH INFECTION AND CHANGES OF TUMOR NECROSIS FACTOR α IN RATS[J];Acta Acadimae Qingdao Umvesitatis;2005-01
2 ZHENG Xiu-li,FENG Quan-sheng,YANG Yu,et alChengdu University of TCM(Chengdu 610075);Effect of Sheng Ya Ling on TNF-α and iNOS in Lung Injury Rats with Endotoxic Shock[J];Journal of Chengdu University of Traditional Chinese Medicine;2008-03
3 Du Xiang,Zhu XiaochunThe General Hospital of Tibet military command;Changes of Plasma Level of IL-6,IL-8 and C_(3a) in Patients with Early High Altitude Pulmonary Edema[J];Journal of High Altitude Medicine;2007-02
4 ZHU Gui-jun1,YU Zhan-biao2,HU Zhen-jie1,ZHANG Yu-xiang1(1.Department of Intensive Care Unit,the Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China;2.Department of Intensive Care Unit,the Affiliated Hospital of Hebei University,Baoding 071000,China);EFFECT OF DIALLYL TRISULFIDE ON TNF-α AND IL-1β IN MICE WITH ACUTE LUNG INJURY INDUCED BY LIPOPOLYSACCHARIDE[J];Journal of Hebei Medical University;2007-04
5 GENG Linlin1),DU Jiang1),FENG Zhichun2) 1) Department of Pediatrics,Zhujiang Hospital,Southern Medical University,Guangzhou 510280 2) Institute of Pediatrics,Beijing Command Hospital of the PLA,Beijing 100700;Expression of TGF-β_1 in lung tissue of new-born rabbits with bronchopulmonary dysplasia[J];Journal of Zhengzhou University(Medical Sciences);2008-03
6 Qin Xuebing, Yu Senyang. Department of Respiratory, South Building, General Hospital of PLA, Beijing 100853, China;Expression of heat shock protein 70 and nuclear factor-κB in ventilator-induced lung injury in rabbit[J];Medical Journal of Chinese People's Liberation Army;2006-05
7 WANG Xinying, LI Weiqin, LI Ning, LI Jieshou. General Surgery Department, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002,China;Role of NF-κB activation in lipopolysaccharide inhibitting albumin expression in rat hepatocytes[J];Journal of Emergency Medicine;2005-03
8 HU Xiaomin, YIN Xiaotao, YIN Wen, LI Yuecai. Department of Emergency Medicine,Xijing Hospital ,the Fourth Military Medical University ,Xi'an 710032,China;Effects of Ligustrazini on activation of NF-κB in pulmonary alveolar macrophages(PAM) in rabbits[J];Journal of Emergency Medicine;2005-09
9 LU Guohua DAN Renfei ZHOU Jianying YAO Hangping. Department of Pulmonary Diseases,First Affiliated Hospital,Medical College Of Zhejiang University,Hangzhou 310003,China;Protective effect of Ginaton on lipopolysaccaride-induced acute lung injury in rats[J];Chinese Journal of Emergency Medicine;2006-08
10 LIU Fen ZENG Zhenguo JIANG Rong ZHU Feng NIE Cheng QIAN Kejian LV Nonghua.Intensive Care Unit,The First Hospital Affiliated to Nanchang University,Nanchang 330006,China;Effects and the mechanism of high volume hemofiltration on acute lung injury induced by endotoxin in dogs[J];Chinese Journal of Emergency Medicine;2006-10
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