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《Journal of Emergenoy Medicine》 2002-01
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The dissociation of angiotensin Ⅱ and aldosterone in patients with multiple organ dysfunction syndrome

HUO Kaixiu,ZHONG Rong.Central Hospital of Longgang,Shenzhen 518116,China  
Objective To investigate the dissociation of angiotensin Ⅱ(AngⅡ) and aldosterone(ALD) in patients with multiple organ dysfunction syndrome(MODS).Methods Plasma levels of cortisol(COR)?AngⅡ and ALD were measured by radioimmunoassay in 25 patients with MODS(Group A)and 35 normal adults(Group B).Results ①The COR and AngⅡ Concentrations of group A were significantly higher than those of group B(P0 01).The plasma level of ALD in group A(191 44±59 83)nmol/L was obviously lower than that in group B(234 51±28 310)nmol/L(P0 01).②Among 25 patients with MODS,had lower ALD 56%(14/25),and 12%(3/25)had higher ALD.③The mean blood pressures in lower ALD group(6 23±2 19kPa)was significantly lower than those in higher ALD group(7 98±1 97kPa,P0 05).The number of dysfunctional(3 21±0 73)and death rate(85 71%)in lower ALD group were obviously higher than those(2 45±0 69)%,45 45% in higher ALD group(P0 05).Conclusions It is not rare to see the dissociation of AngⅡ and ALD in patients with MODS.This predicts more severe disease,worse prognosis and higher death rate in patients with MODS.and dissociation of AngⅡ and ALD.The clinical significance and mechanism of dissociation of AngⅡ and ALD in patients with MODS were briefly discussed.
【CateGory Index】: R459.7
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