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Effects of nuclear factor-κB activation on acute lung injury

Guo Zhenghui,Hong Xin,Mao Baoling,et al.Department of Instisute of Respiratory Disease,Xingqiao Hospital,Third Military Medical University,Chongqing 400037,China [  
Objective To investigate the effects of Nuclear Factor-κ B(NF-κ Β)activation on acute lung injury(ALI).Methods The change of NF κ Β activity was measured by using EMSA,the expression of tumor necrosis factor(TNF-α)content by ELISA and the pathologic change with microscope in pulmonary tissue of rats with LPS induced ALI.Results Both NF κ Β activity and TNF_α content in pulmonary tissue of rats with were increased signficantly.Conclusion LPS led to NF κ B activation and NF κ B upregulated the expression of TNF_α in lung tissue of rats with ALI.The inappropriate activation of NF κ B and excessive expression of TNF_α play important roley in pathogenesis of LPS induced ALI. [
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