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《Journal of Emergency Medicine》 2003-09
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Effects of nuclear factor-κB activation on acute lung injury

Guo Zhenghui,Hong Xin,Mao Baoling,et al.Department of Instisute of Respiratory Disease,Xingqiao Hospital,Third Military Medical University,Chongqing 400037,China [  
Objective To investigate the effects of Nuclear Factor-κ B(NF-κ Β)activation on acute lung injury(ALI).Methods The change of NF κ Β activity was measured by using EMSA,the expression of tumor necrosis factor(TNF-α)content by ELISA and the pathologic change with microscope in pulmonary tissue of rats with LPS induced ALI.Results Both NF κ Β activity and TNF_α content in pulmonary tissue of rats with were increased signficantly.Conclusion LPS led to NF κ B activation and NF κ B upregulated the expression of TNF_α in lung tissue of rats with ALI.The inappropriate activation of NF κ B and excessive expression of TNF_α play important roley in pathogenesis of LPS induced ALI. [
【Fund】： 解放军“十五”医学基金项目 ( 0 1MA0 3 7)
【CateGory Index】： R563
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【References】
Chinese Journal Full-text Database 6 Hits
1 LUO Zhen-chun1,HUANG Yan2,QIN Kai-xiu1,LING Zong-xiu1(1Department of Emergency,2Department of Anesthesiology,Second Affiliated Hospital,Chongqing Medical University,Chongqing 400010,China);Effect of ginkgolide B on NF-κB expression in pulmonary tissue of mice with acute lung injury[J];Acta Academiae Medicinae Militaris Tertiae;2009-14
2 JIANG Jing-jing,SHI Xue-yin,YUAN Hong-bin,ZHU Qiu-feng,WANG Cheng-cai,SUN Hai-jing.Department of Anesthesiology,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China;Effects of ulinastatin on NF-κB expression in lung tissue of rats with acute lung injury[J];Medical Journal of Chinese People's Liberation Army;2009-05
3 GONG Xiaohui, HU Xiaowei, SUN Bo. Laboratory of Pediatric Respiratory and critical Care Medicine, Children's Hospital of Fudan University, Shanghai 200032, China;Effects of inhaled nitric oxide on denovo synthesis of phosphatidylcholine in adult rat lungs with endotoxin-induced inflammatory injury[J];Journal of Emergency Medicine;2004-06
4 LI Yuan-yuan,LIU Hong,LI Fang-fang(ICU,First Clinical Medical College,Shanxi Medical University,Taiyuan 030001,China);Influence of ulinastatin on nuclear factor-κB (NF-κB) expression in rats with lipopolysaccharide-induced acute kidney injury[J];Journal of Shanxi Medical University;2008-03
5 YANG Ai-dong,LI Wen-wen,WANG Dong-ying,et al Shanghai University of Traditional Chinese Medicine(Shanghai 201203);Effects of Hujin Decoction on Expression of NF-κ B mRNA in the Rats with Acute Lung Injury[J];Journal of Emergency in Traditional Chinese Medicine;2009-10
6 Zhang Shubo,Li Baoyong,Gao Xiaozeng,et al.Department of anaesthesia,hebei united university afiliated hospital,Tangshan 063000,China;THE PROTECTIVE EFFECTS OF SEVOFLURANE ON LUNG ISCHEMIA REPERFUSION INJURY IN RATS[J];Chinese Journal of Coal Industry Medicine;2011-08
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 SHI Zengli,LIU Feng,YU Xiaoling, et al (Department of Pathophysiology,Binzhou Medical College,Binzhou 256603);EXPERIMENTAL RESEARCH ON CHANGES OF FACILITATIVE INFLAMMATORY CELL FACTORS AND INFLAMMATORY CELLS IN SEPTICEMIC RATS[J];Journal of Binzhou Medical College;2004-04
2 QIN Kai-xiu,JIAN Hua-gang(Department of Emergency,Second Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400010,China);Expression of inflammatory media in acute lung injury induced by endotoxin in mice[J];Chongqing Medicine;2007-04
3 RAN Peng(Department of Respiration,Cancer Hosipital of Guizhou Province,Guiyang 550005,China);Diagnosis and treatmeat on acute respiratory distress syndrome after pulmonary contusion[J];Chongqing Medicine;2008-16
4 ;Treatment experience of ARDS after chest trauma by PEEP[J];Journal of Traumatic Surgery;2007-01
5 CHEN Yu,ZHANG Lei,WANG Li-ming,ZHU You-hua,ZENG Li,HAN Shu,ZHAO Wen-yu,FU Shang-xi Organ Transplantation Institute of PLA,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China;Application of passive immunotherapy in renal transplant patients with severe pneumonia[J];Academic Journal of Second Military Medical University;2011-04
6 Feng Shi-jun Department of ICU,Hospital of Qiyang People,Qiyang 426100,China;Experience of Using Large Dosage Mucosolvan and End-expiratory Positive Pressure Mechanical Ventilation in 30 Patients with Acute Respiratory Distress Syndrome[J];Chinese Journal of Medicinal Guide;2008-01
7 SUN Jian,ZHAO Ji-guang,ZHENG Liu-ying,LEI Ming-ming,GUO Hui-jiao,YANG Chun-yan,WU Zhe(The Second Hospital of Jilin University,Changchun 130041,China);Effect of chemotatic factor FKN on NF-κB and TNF-α expression in peripheral blood monocytes and intervention of Captopril[J];Journal of Dalian Medical University;2007-05
8 Zhao Ziwen, Zhang Fuchun, Xu Min, et al. Guangzhou Municipal Frist People's Hospital, Guangzhou 510180;Clinical analysis of 190 cases of outbreak with atypical pneumonia in Guangzhou in spring, 2003[J];Guangdong Medical Journal;2003-S1
9 ;显性吸入性肺炎及其所致急性呼吸窘迫综合征的临床分析[J];International Medicine & Health Guidance News;2006-07
10 Yang Zhengping;et al(Qinghai Provincial People's Hospital);CLINICAL OBSERVATION OF PATIENTS WITH ARDS AT MIDDLE ALTITUDE[J];JOURNAL OF HIGH ALTITUDE MEDICINE;1998-01
China Proceedings of conference Full-text Database 1 Hits
1 ZHAO Zi-wen , ZHANG Fu-chun, XV Min, HUANG Kan, ZHONG Wei-nong, CAI Wei-ping, YIN Chi-bi-ao, HUANG Shao-dan, DENG Zhe-tong, WEI Min. Guangzhou Municipal First People's Hospital, Guangzhou 510180, China;Clinical analysis of 190 cases of outbreak with atypical pneumonia in Guangzhou in spring, 2003[A];[C];2003
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Lan Hong, Lu You-Yong Beijing Laboratory of Molecular Oncology,Beijing Institute for Cancer Research,School of Oncology, Peking University, Beijing,100034, P.R.China;Effect of Allitridi on Cyclin D1 and p27~(Kip1) Protein Expression in Gastric Carc inoma BGC823 Cells[J];Chinese Journal of Cancer;2003-12
2 ZHANG Fan (Capital College of Physical Education, Beijing 100088);Research Progress of 1,6-disphosphate Applying on Sports[J];Journal of Beijing Teachers College of Physical Education;2003-03
3 Shi Changyong (Liaoning Academy of TCM, Liaoning);Elaboration of Treatise on Collateral Disease[J];;1992-04
4 Lu　Changjun Li　Ming,e Liu　Junying,et　al(Department　of　Respiratory,Affiliated　Hospital,Binzhou　Medical　College,256603);ISOLATION AND CHARACTERIZATION OF INTERSTITIAL MACROPHAGES FROM RAT LUNG[J];JOURNAL OF BINZHOU MEDICAL COLLEGE;1998-01
5 Zhang Zhiyong,Guo Menghe, Li Guangwen,et al. (Department of Thoracic Surgery,88th Hospital of PLA,Taian 271000) 〔;Analysis of the Characteristics and Treatment of 116 Cases with Thoracic Injuries in Traffic Accident[J];JOURNAL OF TRAUMATIC SURGERY;2000-01
6 Jia Jian,Jin Hongbin,Wang Ji (Tianjin Emergency and Traumatology Center,Tianjin Hospital,Tianjin 300211) 〔;Features of Multiple Trauma and the Countermeasures aginst It[J];JOURNAL OF TRAUMATIC SURGERY;2000-01
7 MA Xiao lin, YANG Zhi huan, WANG Zheng guo,et al. (Department of General Surgery, Daping Hospital, Third Military Medical University, Chongqing,China 400042);Establishment of stretch injury model of in vitro cultured primary liver cells and observation on changes of their cytoskeleton and viscoelasticity[J];Journal of Traumatic Surgery;2001-01
8 LU Jia kai,YANG Zhi huan,JIANG Jian xin, et al. (Surgery Institute of Daping Hospital, Third Military Medical University,Chongqing,400042 China);Establishment of a lung contusion combined with endotoximia induced lung injury model and its early characteristics of lung inflammation response[J];Journal of Traumatic Surgery;2001-03
9 LIAO Ke long,ZHU Pei fang, WANG Zheng guo,et al. (Department of Cardiothoracic Surgery,Southwestern Hospital,Third Military Medical University, Chongqing, 400038, China);An animal model of lung injury following impact thoracic trauma in rats[J];Journal of Traumatic Surgery;2001-04
10 HUANG Xian kai,JIANG Yao guang,ZHOU Jian,et al. (Department of Traumatic Surgery,Daping Hospital,Third Military Medical University,Chongqing 400042,China);Characteristics and management of injury in patiens with severe multiple trauma[J];Journal of Traumatic Surgery;2002-06
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 WANG Xu-dong1, LU Ya-li1, LAI Ren-chun1, LI Yan-ping2, HUANG Wan1, XU Mei1 1Department of Anesthesiology, Oncology Center, Sun Yat-sen University, Guangzhou 510060, China; 2Department of Anesthesiology, Second Affiliated Hospital of Sun Yat-sen University, Guangzhou 510120, China;Protective effect of ketamine against acute rat lung injury induced by liopolysaccharide and its mechanism[J];Journal of Southern Medical University;2007-12
2 Ni Zhiyu,Cong Bin,Dong Mei,Ma Chunling,Li Shujin,Wen Di,Xu Zhilu(Department of Forensic Medicine,Hebei Key Laboratory of Forensic Medicine,College of Basic Medicine,Hebei Medical University,Shijiazhuang,Hebei Province,050017,China);Effect of cholecystokinin octapeptide on IL-1β,IL-6 and IL-10 expression in LPS-induced RAW 264.7 cells[J];Journal of Third Military Medical University;2011-22
3 ZHU Yourong, GONG Xiaohui, LV Yong, et al.Laboratory of Pediatric Respiratory and Intensive Care Medicine, Childrens Hospital, Fudan University,Shanghai 200032, China;Surfactant and inhaled nitric oxide in treatmont of acute lung injury induced by escherichia coli peritonitis in pigs[J];Journal of Emergency Medicine;2004-10
4 PENG Xia,MA Jianfei,LI Chengcheng,et alDepartment of Nephrology,The First Affiliated Hospital China Medical University,Shenyang (110001);Effect of Ulinastatin on Lipopolysaccharide-induced Interleukin 15,Interleukin 6 Expression in Rat Peritoneal Mesothelial Cells[J];Chinese Journal of Integrated Traditional and Western Nephrology;2010-10
5 AN Hai-yan,YANG Ba-xian,LI Zhi-hong,et al.Department of Anesthesiology,Peking University People's Hospital,Beijing 100044,China;Effects of isoflurane on synthesis of phosphatidylcholine in adult rat lungs[J];The Journal of Clinical Anesthesiology;2007-09
6 TIAN Xian-feng,LIU Yong-wang(Department of Emergency,The Central Hospital of Baotou City,Baotou 014040 China);Inhibitory Effects of Taurine on the Expression of NF-κB During Acute Lung Injury in Rats[J];Inner Mongolia Medical Journal;2010-09
7 Zhou haiqiang,Dai yue Department of Pharmacology of Chinese Materia Medica,China Pharmaceutical University,Nanjing 210009,China;Research advances of active constituents of traditional Chinese medicines for treating acute lung injury[J];Chinese Journal of Ethnomedicine and Ethnopharmacy;2011-12
8 LI Ya-qing,XU Wu-lin,YAN Jian-ping,XIA Ying-jie,WANG Hong.Department of Respiratory Medicine,Zhejiang Provincial People's Hospital,Hangzhou 310014,China;Effect of Toll-like receptor-4 and NF-κB on expression of matrix metalloprotease 9 induced by lipopolysaccharide in human airway epithelial cells[J];Medical Journal of Chinese People's Liberation Army;2011-10
9 CHEN Xiao-bing,XU Tie,LI Xiao-min,et al.Center of Emergency,First People's Hospital of Lianyungang,Affiliated Hospital Xuzhou Medical College,Lianyungang 222001,China;Explore the Effection and Machanism of Different Doses of Ulinastatin in Septic[J];Journal of Clinical Rational Drug Use;2011-29
10 ZHANG Jun-yi2,DING Chun-hua1,SUO Xiao-hua3,DONG Cai-feng2,LING Yi-ling1(1.Department of Pathophysiology,The School of Basic Medical Science,Hebei Medical University,Shijiazhuang 050017;2.The School of Medicine,Chifeng University,Chifeng 024000;3.Department of Pathology,Shijiazhuang Traditional Chinese Medical Hospital,Shijiazhuang 050051,China);EFFECTS OF MELATONIN ON ANTI-OXIDATIVE FUNCTION OF LUNG INJURY INDUCED BY LIPOPOLYSACCHARIDE IN RATS AND ICAM-1 EXPRESSION[J];Chinese Journal of Applied Physiology;2008-04
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