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《Journal of Emergency Medicine》 2004-05
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The mechanisms of radix salviae miltiorrhizae in prevention of left ventricular hypertrophy in spontaneously hypertensive rats

LIU Feng, ZHENG Zhi. Department of Emergency Medicine,Tongji Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430030, China  
Objective To observe the effects of radix salviae miltiorrhizae(RSM) on left ventricular hypertrophy (LVH) model in spontaneously hypertensive rats (SHRs),and investigate its mechanisms.Methods 18 8-week-old SHRs were divided into three groups at random.The rats in group one were killed at 8 weeks.RSM or distilled water[1mg/(kg·d)]was injected through intraperitoneally for 10 weeks. Systolic blood pressure (SBP) and left ventricular mass index(LVMI)were measured.The norepinephrine (NE),dopamine(DA),adnephrin(E) and superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),lactoperoxidase(LPO),angiotensin Ⅱ (Ang Ⅱ) expression in the left ventricular tissue of SHRs were measured.Results ① Compared with hypertension group, the SBP and LVMI were significantly lower after using RSM.② RSM more effectively prevented the depletion of NE, DA and elevation of E produce in myocardial than distilled water.③RSM promoted the SOD,GSH-Px activities and decreased LPO produce in myocardia.④RSM significantly prevented the increase of Ang Ⅱ content in LVH tissue.Conclusion RSM may effectively prevent and treat the LVH of SHRs.The effect of RSM on anti-hypertrophy is associated with regulating and improving the metabolism of catecholamine and oxygen-derived,free radicals in the heart,and is closely associated with inhibiting the metabolism of RAS.
【Fund】: 湖北省自然科学基金资助项目 ( 2 0 0 0J0 64 )
【CateGory Index】: R259
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