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《Journal of Emergency Medicine》 2004-10
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Surfactant and inhaled nitric oxide in treatmont of acute lung injury induced by escherichia coli peritonitis in pigs

ZHU Yourong, GONG Xiaohui, LV Yong, et al.Laboratory of Pediatric Respiratory and Intensive Care Medicine, Childrens Hospital, Fudan University,Shanghai 200032, China  
Objective To investigate efficacy of prophylactic surfactant and inhaled nitric oxide(iNO) in alleviating the acute lung injury. Methods Thirty piglets (body weight 6 to 9 kg) were randomly allocated to either a negative control group (group N, n=6) with only normal saline and groups with escherichia coli (n=6 each) followed by treatment with: (1)a positive control with mechanical ventilation only (group C),(2) iNO at 10 ppm (group NO),(3) surfactantat 100 rog/kg (group Surf),(4) both surfactant and iNO the same as in groups of NO and Surf (group SNO). Arterial blood gas, dynamic lung compliance (Cdyn) were measured every 12 h. At the end, the lungs were used for biochemical and histopathological analysis. Results Group SNO had the highest PaO 2/FiO 2 and Cdyn values.Values for PaO 2/FiO 2, Cdyn and Rrs in group NO were similar to those in the group C. Both biochemical analysis of bronchoalveolar lavage fluid and morphological measurement supported that SNO had the best effects in lung protection in contrast to NO that had only transient effect on oxygenation. Conclusion The combination of Surf and iNO treatment can alleviate piglet ALI induced by Escherichia coli peritonitis, reflected by improved oxygenation, lung mechanics, alveolar expansion,and permeability.
【Fund】: 国家自然科学基金项目 ( 3 0 170 989);; 上海市科委优秀学科带头人资助
【CateGory Index】: R563.8
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