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《Journal of Emergency Medicine》 2004-10
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Surfactant and inhaled nitric oxide in treatmont of acute lung injury induced by escherichia coli peritonitis in pigs

ZHU Yourong, GONG Xiaohui, LV Yong, et al.Laboratory of Pediatric Respiratory and Intensive Care Medicine, Childrens Hospital, Fudan University,Shanghai 200032, China  
Objective To investigate efficacy of prophylactic surfactant and inhaled nitric oxide(iNO) in alleviating the acute lung injury. Methods Thirty piglets (body weight 6 to 9 kg) were randomly allocated to either a negative control group (group N, n=6) with only normal saline and groups with escherichia coli (n=6 each) followed by treatment with: (1)a positive control with mechanical ventilation only (group C),(2) iNO at 10 ppm (group NO),(3) surfactantat 100 rog/kg (group Surf),(4) both surfactant and iNO the same as in groups of NO and Surf (group SNO). Arterial blood gas, dynamic lung compliance (Cdyn) were measured every 12 h. At the end, the lungs were used for biochemical and histopathological analysis. Results Group SNO had the highest PaO 2/FiO 2 and Cdyn values.Values for PaO 2/FiO 2, Cdyn and Rrs in group NO were similar to those in the group C. Both biochemical analysis of bronchoalveolar lavage fluid and morphological measurement supported that SNO had the best effects in lung protection in contrast to NO that had only transient effect on oxygenation. Conclusion The combination of Surf and iNO treatment can alleviate piglet ALI induced by Escherichia coli peritonitis, reflected by improved oxygenation, lung mechanics, alveolar expansion,and permeability.
【Fund】: 国家自然科学基金项目 ( 3 0 170 989);; 上海市科委优秀学科带头人资助
【CateGory Index】: R563.8
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1 GONG Xiaohui, HU Xiaowei, SUN Bo. Laboratory of Pediatric Respiratory and critical Care Medicine, Children's Hospital of Fudan University, Shanghai 200032, China;Effects of inhaled nitric oxide on denovo synthesis of phosphatidylcholine in adult rat lungs with endotoxin-induced inflammatory injury[J];Journal of Emergency Medicine;2004-06
Chinese Journal Full-text Database 1 Hits
1 AN Hai-yan,YANG Ba-xian,LI Zhi-hong,et al.Department of Anesthesiology,Peking University People's Hospital,Beijing 100044,China;Effects of isoflurane on synthesis of phosphatidylcholine in adult rat lungs[J];The Journal of Clinical Anesthesiology;2007-09
Chinese Journal Full-text Database 10 Hits
1 QIN Shi wen,SHI Yuan,LI Hua qiang,et al. (Department of Pediatrics,Daping Hospital,the Third Military Medical University,Chongqing 400042,China);An experimental study on the effects of carbon monoxide inhibitor in septic shock[J];Chongqing Medical Journal;2004-04
2 TAN Zhao-hua,XU Jun-mei, YANG Zhao-yun,et al. Department of Anesthesiology, The Second Xiangya Hospital, Central South University,changsha 410011,China;The Effects of Ulinastatin on Proinflammatory Cytokine and Oxygen Free Radicals During Acute Lung Injury in Rabbits[J];Journal of Chinese Physician;2004-10
3 WANG Yue, LI Jin Bao *, DENG Xiao Ming, ZHU Ke Ming, LI Wen Xian (Department of Anesthesiology, Changhai Hospital, Second Military Medical University, Shanghai 200433,China);Nitric oxide inhalation in treatment of oleic acid-induced acute respiratory distress syndrome in canines[J];Academic Journal of Second Military Medical University;2002-07
4 Sun Gengyun; Qian Guisheng; Wu Gnoming; Zhao Zhiqiang; Mao Baoling (Research Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing,400037);Clinical study of diagnosis and treatment of acute respiratory distress syndrome[J];ACTA ACADEMIAE MEDICINE MILITARIS TERTIAE;1998-04
5 ZHANG Jian 1, LI Huan Zhang 1, QI Hao Wen 1, HUANG Weng Jing 2, CHEN Bing Fu 2, YIAN Pei Song 3 1Department of Respiratory Diseases, Xijing Hospital, 2Institute of Neurosciences of Chinese PLA, 3Department of Pathology, Facul;NF-kB expression in LPS induced acute lung injury in mice[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;2000-02
6 WANG Yong jian 1,PENG Pin xian 2,ZHANG Ben gu 1,LIANG Jian hui 2 (Department of Thoracic Surgery,The Peking University Shenzhen Hospital,Shenzhen,518036; Dept of Thoracic Surgery,Second Affiliated Hospital,Guangzhou Medical College);Study of Effects of Milrinone on Isolated lung Preservation[J];Academic Journal of Guangzhou Medical College;2003-01
7 Chen Chang,Xia Zhongyuan,Wang Xiaoyuan,et al Department of Anesthesiology, Renmin Hospital, Wuhan University, Wuhan 430060, China;Effect of Radix Paeoniae Rubra on Expression of iNOS and eNOS in Lipopolysaccharide-induced Acute Lung Injury[J];Journal of Hubei Medical University;2005-01
8 GAO Yan, GAO Mei, AN Zhijie Harbin 242 hospital, 150066;Clinical Significance of IL-13、TNF-α concentrations in sputum and serum of asthmatic patients[J];Aerospace Medicine;2004-01
9 LUO Zi-qiang1, FENG Dan-dan1, YUE Shao-jie2, et al. (1.Department of Physiology, Xiangya School of Medicine,Central South University,Changsha 410078; 2.Departmen of Pediatrics,Xiangya Hospital, Central South University, Changsha 410008,China);Effect of Shenfu injection on the synthesis of pulmonary surfactant in cultured lung explants[J];Bulletin of Hunan Medical University;2003-02
10 ZHAO Gaofeng,BA Yufeng,QI Yu, LI Xiangnan, QIN Jianjun, LI Ang Department of Thoracic Surgery, the First Affiliated Hospital, Zhengzhou University; the Key Laboratory of Clinical Medical Sciences of Universities in Henan Province, Zhengzhou 450052;Changes of ICAM-1 expression in transplanted lung tissue at early stage of rabbit pulmonary transplantation[J];Journal of Zhengzhou University(Medical Sciences);2006-04
【Secondary References】
Chinese Journal Full-text Database 4 Hits
1 Yang Xiaoming, Xue Xiaodong, Zhang Guorong, et al. Department of Anesthesiology, General Hospital of Airforce, Beijing 100036, China;Effects of inhalation of endothelin-A receptor antagonist on experimental acute lung injury[J];Medical Journal of Chinese People's Liberation Army;2008-05
2 LI Li-na,WANG Qing-guo(Beijing University of Chinese Medicine,Beijing 100029);Discuss on TCM pathogenesis of acute lung injury from qi,blood and water[J];Journal of Beijing University of Traditional Chinese Medicine;2008-05
3 XU Wenli1,HE Jun1,ZENG Yinming1,PANG Qingfeng1,2(1.Jiangsu Province Key Laboratory of Anesthetic and Analgesic Application Technology,Xuzhou,Jiangsu 221002,China;2.Department of Pathophysiology,Xuzhou Medical College,Xuzhou,Jiangsu 221002);The protective effect of isoflurane post-treatment on the acute lung injury induced by cecal ligation and puncture in rats[J];Acta Academiae Medicinae Xuzhou;2010-05
4 YIN Wen, LIU Jian, HUANG Yang, et al.Department of Emergency, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, China;Mechanism and current therapies of acute lung injury[J];Chinese Journal of Critical Care Medicine;2008-09
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Guo Zhenghui,Hong Xin,Mao Baoling,et al.Department of Instisute of Respiratory Disease,Xingqiao Hospital,Third Military Medical University,Chongqing 400037,China [;Effects of nuclear factor-κB activation on acute lung injury[J];Journal of Emergency Medicine;2003-09
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