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《Journal of Emergency Medicine》 2005-06
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Changes of serum neutrophil elastase activity in patients with acute lung injury

JIE Zhijun, LUO Yong, XU Weiguo,LIN Jianhai,SONG Zhifang,CAI Yingyun. Department of Pulmonolgy, Xinhua Hospital, Shanghai Second Medical University,Shanghai 200092,China  
Objective To study the change of serum neutrophil elastase (NE) activity in patients with acute lung injury (ALI). Method Twenty-two ALI patients and 15 healthy volunteers (control group) were recruited. The arterial blood gas was recorded to calculate PaO_2/FiO_2 ratio in ALI group. The activity of NE, the concentration and activity of α_1-antitrypsin (α_1-AT), the serum concentration of interleukin-6 (IL-6) and interleukin-8 (IL-8) were measured. Results In ALI group, the activity of serum NE and the concentration of IL-6 and IL-8 were significantly higher than those of control group (P0.01). The activity of α_1-AT in ALI group was significantly lower than that in control group (P0.05). The activity of serum NE in non-survious (n=10) was significantly higher than that of survival group (n=12, P0.01). Moreover, the activity of serum NE in ALI patients was inversely related to their PaO_2/FiO_2 ratio (r=-0.874, P0.01). Conclusion In ALI patients, the activity of serum NE was significantly elevated, but the activity of α_1-AT was reduced. There was an imbalance between protease and antiprotease. The activity of serum NE was significantly related to the severity and prognosis of ALI patients.
【CateGory Index】: R563
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